Imaging correlates of early pathology in Parkinson’s disease

Seminar | April 3 | 11 a.m.-12:30 p.m. | 1102 Berkeley Way West

 Johannes Klein, Nuffield Dept. of Clinical Neuroscience, Oxford University

 Neuroscience Institute, Helen Wills

Parkinson’s disease affects around 1% of the population over 60, and the number of patients is rising with an aging population. To develop neurodegenerative therapies aiming to prevent conversion to or slow down progression of Parkinson’s, reliable biomarkers are needed to identify those at risk of PD, and to track disease progression. Detecting early pathology would allow for intervention before motor symptoms appear. Arguably, the potential for intervention success is higher in the pre-motor phase when neurodegeneration is still limited.In this talk, I will present neuroimaging measures that offer insight into early brain pathology in Parkinson’s disease, and in persons at risk of developing Parkinson’s. I will also present data on extra-striate pathology in prodromal patients, providing new insight into disease mechanisms driving non-motor symptoms of the disease.

 CA,, 5106649902