An Update on Cardiac ASL-MRI and Brain Tumor DCE-MRI

Seminar | May 2 | 12-1 p.m. | 106 Stanley Hall

 Krishna Nayak, University of Southern California

 Bioengineering (BioE)

This talk will summarize two of the translational MRI efforts in my lab. One is the application of arterial spin labeling (ASL) to the human heart. ASL is a non-contrast technique for measuring tissue perfusion, and could be extremely valuable in the assessment of ischemic heart disease, especially high-risk groups such as those with kidney failure. Cardiac ASL-MRI is challenging because of the heart’s motion, and complex geometry of the blood supply. The second project is the improvement of dynamic contrast enhanced (DCE) MRI of brain tumors. DCE-MRI is a potentially powerful technique for measuring kinetic parameters, which are important in determining progression of disease and effectiveness of treatments. Our work is focused on the use of sparse sampling and model-constrained reconstruction to produce a more comprehensive and reproducible test.