BioE Seminar: “Remodeling of cell surfaceome proteomes in cancer”

Seminar | February 8 | 12-1 p.m. | 290 Hearst Memorial Mining Building

 Jim Wells, UCSF

 Bioengineering (BioE)

Spring 2017 Seminar Series

Wednesday, February 8
12noon - 1:00pm
290 Hearst Mining Building

“Remodeling of cell surfaceome proteomes in cancer”

Jim Wells
Professor of Pharmaceutical Chemistry

The cell surface proteome is the primary hub for cells to communicate with the outside world. Surface proteins are control buttons that regulate cell growth, nutrient uptake among others, cell-cell contact and signal the immune system if the cell is friend or foe. Once cells become cancerous they undergo tremendous morphological changes. My lab studies how the surfacome is remodeled. We find the new set of proteins promote enhanced cell growth and detachment from native tissues allowing metastasis. Our primary goal is to systematically understand how cancer cells remodel their membrane proteomes (surfaceomes) during cancer transformation. We use this information to generate recombinant antibodies, natural proteins that can detect and attack the cancer.