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<< Week of January 15 >>

Monday, January 14, 2019

Architecture and Co-Evolution of Allosteric Materials

Seminar | January 14 | 4-5 p.m. | 106 Stanley Hall

Matthieu Wyart, Ecole Polytechnique Federale de Lausanne

QB3 - California Institute for Quantitative Biosciences

We introduce a numerical scheme to evolve functional elastic materials that can accomplish a specified mechanical task. In this scheme, the number of solutions, their spatial architectures and the correlations among them can be computed. We first consider an “allosteric” task, which requires the material to respond specifically to a stimulus at a distant active site. We find that functioning......   More >

Thursday, January 17, 2019

Developmental lineage mapping by genomic barcoding in the mouse

Seminar | January 17 | 10-11 a.m. | 290 Hearst Memorial Mining Building

Reza Kalhor, Wyss Institute Research Associate in Technology Development

Bioengineering (BioE)

Cellular barcoding using nuclease-induced DNA mutations is an effective approach that is emerging for recording biological information, including developmental lineages. We introduce the homing CRISPR system as an effective means of generating DNA barcodes with a high and scalable diversity. We further describe the implementation of this system in a mouse model with multiple......   More >