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“Listening in on crosstalk in signaling networks”

Seminar: BioE Seminars | September 27 | 12-1 p.m. | 290 Hearst Memorial Mining Building

Lani Wu, UCSF

Bioengineering (BioE)

How complex signaling networks shape highly-coordinated, multistep cellular responses is poorly understood. Biological networks are highly complex, containing many components and many putative interactions. We developed a network-perturbation approach to identify where and when signaling actually occurs. Our results, illustrated on polarity networks in neutrophils and morphogenic networks in colonic cells, suggest that the paths of signal transduction can be quite dynamic, yet at any given time simpler than previously appreciated.