Cell types, and the specificity of synaptic connectivity and signaling between them, in primary visual cortex

Seminar: Neuroscience Seminar | January 22 | 2-3:30 p.m. | 177 Life Sciences Addition

 Dr. Gabe Murphy, Allen Institute

 Neuroscience Institute, Helen Wills

Neurons are frequently classified into distinct groups, or ‘cell types’, on the basis of structural, physiological, or genetic attributes. Constraining the definition and diversity of neuronal cell types likely requires a different, more integrated approach - e..g, assaying the cellular and network attributes of individual neurons and determining the degree to which those attributes co-vary across large populations of neurons.

In this seminar I’ll describe the degree to which intrinsic electrophysiological and/or morphological properties of GABAergic interneurons categorized into specific, transcriptomically-defined clusters overlap with that of neurons mapped to other transcriptomically-defined clusters; I’ll also describe high-throughput mapping of local synaptic connectivity between excitatory and inhibitory neurons and a path towards constraining the transcriptomic signatures of the pre- and/or postsynaptic cells in such experiments.