AbbVie Seminar in Organic Chemistry: Mechanistic Insights into PTEN Signaling

Seminar | May 8 | 11 a.m.-12 p.m. | 120 Latimer Hall

 Dr. Philip Cole, Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School

 College of Chemistry

The lipid phosphatase PTEN is a key tumor suppressor gene that regulates the level of the phospholipid PIP3 in cells, opposing the action of PI3-kinase. Rising PIP3 promotes cancer cell growth by stimulating Akt protein kinase activity. PTEN function is modulated by phosphorylation and the ubiquitin ligase WWP2. We will discuss our progress on understanding the mechanisms of regulation of PTEN, WWP2, and Akt by intramolecular interactions and post-translational modifications and how these findings may inform the development of anti-cancer strategies.

 Light refreshments will be served at 10:50 at The Coffee Lab, 510-643-0572

 Mechanistic Insights into PTEN Signaling