Order and Chaos*: Collective Behavior of Crowded Drops in Microfluidic Systems: *Crowded droplet breakup HydrodynAmics not Ordered but Stochastic

Seminar | May 9 | 12-1 p.m. | Soda Hall, Wozniak Lounge

 Prof. Sindy KY Tang, Assistant Professor, Stanford University, Department of Mechanical Engineering

 Berkeley Sensor & Actuator Center

Droplet microfluidics, in which micro-droplets serve as individual reactors, has enabled a range of high-throughput biochemical processes. The talk will start with our recent application on using droplets to identify microbes, specifically methane-metabolizing bacteria, for the more efficient generation of bioplastics. Unlike solid wells typically used in current biochemical assays, droplets are subject to instability and can break especially at fast flow conditions. Although the physics of single drops has been studied extensively, the flow of crowded drops or concentrated emulsions - where droplet volume fraction exceeds about 80% - is relatively unexplored in microfluidics. Ability to leverage concentrated emulsions is critical for further increasing the throughput of droplet applications. Prior work on concentrated emulsions focused on their bulk rheological properties. The behavior of individual drops within the emulsion is not well understood, but is important as each droplet carries a different reaction.

This talk examines the collective behavior of drops in a concentrated emulsion by tracking the dynamics and the fate of individual drops within the emulsion. At the fast flow limit, we show that droplet breakup within the emulsion is stochastic. This contrasts the deterministic breakup in classical single-drop studies. We further demonstrate that the breakup probability is described by dimensionless numbers including the capillary number and confinement factor, and the stochasticity originates from the time-varying packing configuration of the drops. To mitigate breakup, we design novel amphiphilic nanoparticles, and show they are more effective than surfactant molecules as droplet stabilizers.

At the slow flow limit, we observe an unexpected order, where the velocity of individual drops in the emulsion exhibits spatiotemporal periodicity. Such periodicity is surprising from both fluid and solid mechanics point of view. We show the phenomenon can be explained by treating the emulsion as a soft crystal undergoing plasticity, in a nanoscale system comprising thousands of atoms as modeled by droplets. Our results represent a new type of collective order not described before, and have practical use in on-chip droplet manipulation. From the solid mechanics perspective, the phenomenon directly contrasts the stochasticity of dislocations in microscopic crystals, and suggests a new approach to control the mechanical forming of nanocrystals.

 Faculty, Staff, Students - Graduate

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