Wednesday, October 16
12noon - 1:00pm
106 Stanley Hall, UC Berkeley
Directed evolution for synthetic biology applications
Wilson and Kathryn Fraser Research Professorship in Biochemistry
The University of Texas at Austin
One of the prevailing notions in the nascent field of synthetic biology is that parts, circuits, and systems that have otherwise been optimized by billions of years of evolution are completely fungible. We have developed methods for the facile evolutionary engineering of enzymes, pathways, and organisms, and will show examples of how novel transcription networks, genetic codes, and organismal consortia can be built using directed evolution. That said, directed evolution is just a waystation to rational design, and progress on computational prediction of macromolecular structure and function will be considered as part of the synthetic biology toolset.