Glenn T. Seaborg Lecture in Inorganic Chemistry: Artificial Metalloenzymes: Challenges and Opportunities

Seminar | October 27 | 4-5 p.m. | 120 Latimer Hall

 Thomas Ward, University of Basel

 College of Chemistry

Artificial metalloenzymes (ArMs) result from the incorportation of a catalyst precursor within a host protein, see Scheme. To engineer such ArMs, we have relied on various cofactor- anchoring strategies including: dative-, covalent- and supramolecular interactions. The resulting hybrid catalysts display features that are reminiscent of both homogeneous catalysts and enzymes. The optimization of the catalytic performance is achieved by combining both chemical- and genetic means. The versatility of these strategies will be illustrated with selected examples covering various host proteins, anchoring strategies and reactions including: (transfer)-hydrogenation, cross-coupling, C–H activation, dihydroxylation, Michael addition, olefin metathesis etc.

 Light refreshments will be served at 3:50 at The Coffee Lab, 510-643-0572