Marine Natural Products: Inspiration for Chemical and Biological Discovery

Seminar | January 17 | 11 a.m.-12 p.m. |  Pitzer Auditorium, 120 Latimer Hall

 Prof. Joshua Pierce, Department of Chemistry, North Carolina State University

 College of Chemistry

Marine natural products often have complex structures and potent biological activities; however, little is understood regarding how their molecular structure correlates with function or what biological targets or pathways are involved. Through rapid and efficient chemical syntheses of bioactive marine natural products we are able prepare ample quantities of material to explore both structure-activity relationships as well as target identification studies. Specifically, the synthesis of the monanchocidin, synoxazolidinone and lipoxazolidinone families of natural products will be discussed leading to novel synthetic derivatives that serve as lead structures for infectious disease and cancer chemical probe and therapeutic development.

 Light refreshments will be served at 10:50am at The Coffee Lab, 510-643-0572