Mechanisms of experience-dependent plasticity in GABAergic circuits: connecting genes to cell-types and circuit-functions

Seminar | April 8 | 1-2:30 p.m. | 177 Life Sciences Addition

 Ivo Spiegel, Department of Neurobiology, Weizmann Institute of Science

 Neuroscience Institute, Helen Wills

The ability to adapt and learn from the experience is essential for an animal’s survival and key questions in neuroscience concern the underlying molecular and cellular mechanisms. In the adult cortex, it was suggested that particularly GABAergic interneurons in the supragranular layers of the cortex play key roles in regulating the experience-dependent plasticity of cortical circuits. However, the mechanisms through which experience alters the connectivity and function of these interneurons remain poorly understood and it is thus unclear what aspects of cortical circuit function are controlled by experience-regulated cellular-molecular mechanisms in supragranular interneurons. In my talk, I will discuss our recent findings on experience-induced mechanisms in subtypes of supragranular GABAergic interneurons and how these mechanisms control sensory processing and plasticity in the adult cortex.