William G. Dauben Lectureship: Integrated Platforms for Predictable Organic Synthesis
Seminar | January 28 | 11 a.m.-12 p.m. | 120 Latimer Hall
Synthetic chemists excel at devising spectacular new reaction pathways and powerful catalytic processes, but few of these advances have been integrated into platforms for the predictable and programable production of complex molecules. Successful examples, such as Fmoc-Solid Phase Peptide Synthesis (SPPS) and DNA synthesis, require not only highly efficient bond forming reactions but also a suitable operating system of protecting groups, solid supports, for analytical methods. Inspired by these successes, our group seeks to develops powerful new coupling reactions that allow the synthesis of larger structures in a predictable manner from a limited number of predefined building blocks. By following this paradigm, we have devised platforms for the 1) the chemical synthesis of small proteins (up to ~25 kDa), 2) the programmable synthesis of rigid, shape-defined saturated N-heterocycles, and 3) the on-demand production of drug-like molecules The ability to confidently and rapidly produce complex molecules from a limited set of building blocks allows integration of technologies including virtual screening, automation, and parallel synthesis.