QB3-Berkeley http://events.berkeley.edu/index.php/calendar/sn/qb3.html Upcoming Events Autocatalytic backbone α-N-methylation of a fungal enzyme generates a novel family of ribosomally-encoded cyclic anti-nematode peptides, Mar 20 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107796&date=2017-03-20 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107796&date=2017-03-20 Special Seminar: "Autocatalytic backbone α-N-methylation of a fungal enzyme generates a novel family of ribosomally-encoded cyclic anti-nematode peptides", Mar 20 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107809&date=2017-03-20 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107809&date=2017-03-20 Ion Channels in the Tubulovesicles , Mar 20 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105265&date=2017-03-20 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105265&date=2017-03-20 From cold sores to encephalitis: herpesvirus invasion of the nervous system, Mar 21 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107782&date=2017-03-21 This seminar is partially sponsored by NIH http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107782&date=2017-03-21 Structure and Dynamics of the Influenza M2 Protein and Plant Cell Walls Determined by Solid-State NMR Spectroscopy, Mar 21 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=104502&date=2017-03-21 High-resolution solid-state NMR spectroscopy is a powerful and versatile method to determine, at atomic resolution, the structure, mobility, and intermolecular interactions of biomolecules in their native environments, thus giving rich insights into the mechanisms of action of biomolecules. I will present our studies of the influenza virus M2 protein and plant cell walls to illustrate this point. M2 is a multifunctional protein of influenza viruses: it serves as a proton channel during virus entry into cells and mediates membrane scission during virus budding. Using 13C, 15N, 1H, 2H, and 19F NMR, we have elucidated the proton conduction mechanism of the M2 channels of both influenza A and B viruses, showing that a key histidine residue in the transmembrane domain forms a mixed hydrogen-bonded chain with water molecules to actively shuttle protons into the virion. The rates, equilibrium dissociation constants, sidechain motions, ring tautomerization, and cation-π interactions of this proton shuttling process have been measured. We determined where the antiviral drug, amantadine, binds in the influenza A M2 channel, and how binding interferes with proton shuttling of histidine. <br /> <br /> In the second project, we bring multidimensional SSNMR to bear on plant cell walls, a complex polysaccharide-rich material that provides mechanical strength to plant cells while allowing plant cells to expand rapidly during plant growth. Because of their insoluble nature, plant cell walls have long been resistant to molecular-level structural characterization. By growing entire plants in 13C-enriched media and harvesting the intact primary cell walls in a hydrated state, we are able to measure 2D and 3D correlation SSNMR spectra of whole cell walls that revealed how cellulose, hemicellulose and pectins interact with each other in model plants of both dicot (Arabidopsis thaliana) and monocot (Brachypodium distachyon) families, how plant cellulose structure differs from bacterial cellulose, and what the minimum size of cellulose microfibrils is in plant cell walls. Finally, using sensitivity-enhancing dynamic nuclear polarization NMR approaches, we determined how a protein, expansin, binds the wall polysaccharide to loosen the cell wall during plant growth. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=104502&date=2017-03-21 Marian E. Koshland Memorial Lecture: Water bears: Probing how animal body plans evolve and how biological materials can survive extremes, Mar 21 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=101212&date=2017-03-21 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=101212&date=2017-03-21 Plant and Microbial Biology Micro Seminar: "When is a fungus not a fungus?", Mar 22 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105129&date=2017-03-22 The primary focus of my research is to determine the evolutionary relationships of the eukaryotes and the cellular and genomic innovations associated with the emergence and diversification of the eukaryotic cell. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105129&date=2017-03-22 BioE Seminar: “Investigating B cell diversity -- Using Nanopore Technology to Improve Single Cell RNAseq.”, Mar 22 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105996&date=2017-03-22 Spring 2017 Seminar Series<br /> <br /> Wednesday, March 22<br /> 12noon - 1:00pm<br /> 290 Hearst Mining Building<br /> <br /> “Investigating B cell diversity -- Using Nanopore Technology to Improve Single Cell RNAseq.”<br /> <br /> Chris Vollmers<br /> Assistant Professor of Biomolecular Engineering<br /> UC Santa Cruz<br /> <br /> Recent advances in molecular biology protocols and sequencing technology have made it possible to analyze the entire transcriptomes of single cells. Applying this single cell RNAseq technology to B and T cells has the potential to uncover the true diversity of the adaptive immune system. However, Illumina sequencing technology, the current gold standard for RNAseq analysis, is not capable to resolve many of the more complex transcript isoforms present in mammalian transcriptomes. Therefore, we have implemented both library preparation protocols and computational tools to use Oxford Nanopore Technology sequencing for the RNAseq analysis of single cells. This has allowed us to identify high diversity among B cell surface receptor isoforms that Illumina sequencing failed to resolve. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105996&date=2017-03-22 Neural Dust, A Platform for Neural Interfaces, Mar 22 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106282&date=2017-03-22 Michel Maharbiz is Professor of Electrical Engineering and Computer Sciences at UC Berkeley. His current research centers on building micro/nano interfaces to cells and organisms and exploring bio-derived fabrication methods. His research group is also known for developing the world’s first remotely radio-controlled cyborg beetles; this was named one of the top 10 emerging technologies of 2009 by MIT’s Technology Review (TR10) and was among Time magazine’s Top 50 Inventions of 2009. His long-term goal is understanding developmental mechanisms as a way to engineer and fabricate machines. <br /> ---------<br /> Free and open to the public. Register online by Monday for a free lunch at UC Berkeley. The CITRIS Research Exchange Seminar Series is a weekly dialogue highlighting leading voices on societal-scale research issues. Each one-hour seminar starts at 12pm Pacific time and is hosted live at Sutardja Dai Hall on the UC Berkeley campus. <br /> <br /> Live broadcast at <a href=" https://www.youtube.com/user/citrisuc/live"> https://www.youtube.com/user/citrisuc/live</a>. All talks may be viewed on our <a href=" https://www.youtube.com/citris"> YouTube channel </a>.<br /> <br /> Live webcasting of each CITRIS Research Exchange seminar is available at these CITRIS campuses:<br /> <br /> CITRIS @ Davis: 1065 Kemper Hall, College of Engineering, UC Davis http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106282&date=2017-03-22 Beyond Academia Careers Networking Event, Mar 22 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106481&date=2017-03-22 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106481&date=2017-03-22 CRISPR-Cas9 gene editing, from mechanism to therapy, Mar 22 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106750&date=2017-03-22 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106750&date=2017-03-22 Inside NSF, Mar 23 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107497&date=2017-03-23 This workshop will explain how NSF is structured, how it functions, and how it reviews proposals, with an eye towards how trends and federal policies affect its work. This session will help faculty apply an understanding of how NSF works to their funding strategies. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107497&date=2017-03-23 CANCELED: Neuroscience Student Seminar Series, Mar 23 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=102369&date=2017-03-23 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=102369&date=2017-03-23 Let's Have an Awesome Time Doing Science!, Mar 29 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107843&date=2017-03-29 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107843&date=2017-03-29 Reprogramming the Brain to Health Symposium, Mar 29 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108081&date=2017-03-29 This symposium will bring together the most distinguished brain scientists to share and learn up-to-date breakthroughs in brain research. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108081&date=2017-03-29 CEND 9th Annual Symposium, Mar 31 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107785&date=2017-03-31 Emerging and neglected diseases are a group of debilitating and often deadly infections. As a group, these diseases are poorly understood and generally lack effective tools for prevention, control, and treatment. CEND Annual Symposium aims to strengthen connections between San Francisco Bay Area scientists working on infectious diseases of global health importance and the broader global health research, product development, and advocacy communities. The symposium features a dynamic list of invited speakers from around the world, including scientists from developing countries. Each March the event attracts over 400 registrants. Participants include academic researchers from UC Berkeley, UCSF, Stanford, UC Davis as well as representatives from local biotechnology and pharmaceutical companies and global health nonprofits. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107785&date=2017-03-31 Cynthia A. Chan Memorial Lecture: Molecular Machines that Build Membranes, Apr 3 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105406&date=2017-04-03 Cynthia A. Chan Memorial Lecture<br /> http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105406&date=2017-04-03 Nonclassical antigen presentation and T cell recognition, Apr 4 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108015&date=2017-04-04 This seminar is partially sponsored by NIH http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108015&date=2017-04-04 EHS 201 Biosafety in Laboratories, Apr 5 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105085&date=2017-04-05 This training is required for anyone who is listed on a Biological Use Authorization (BUA) application form that is reviewed by the Committee for Laboratory and Environmental Biosafety (CLEB). A BUA is required for anyone working with recombinant DNA molecules, human clinical specimens or agents that may infect humans, plants or animals. This safety training will discuss the biosafety risk assessment process and the means to mitigate those risks such as good work practices and personal protective equipment. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105085&date=2017-04-05 Plant and Microbial Biology Micro Seminar: "The ancestral human microbiome: the evolution and ecology of our microbial self", Apr 5 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105130&date=2017-04-05 I am interested in evolutionary medicine and how understanding the ways in which humans have co-evolved with environments, diets, and pathogens allows us to better understand health and disease. My research draws on the methods and theoretical frameworks of several fields, including: molecular biology, archaeology, archaeogenetics (ancient DNA), stable isotope-based paleodietary and paleomigratory analysis, archaeobotany, and zooarchaeology. Links to open-access PDFs of my publications can be found on my Academia.edu and ResearchGate profiles. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105130&date=2017-04-05 BioE Seminar: “Probing the biophysical regulation of de novo tumor microenvironment”, Apr 5 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105997&date=2017-04-05 Spring 2017 Seminar Series<br /> <br /> Wednesday, April 5<br /> 12noon - 1:00pm<br /> 290 Hearst Mining Building<br /> <br /> “Probing the biophysical regulation of de novo tumor microenvironment”<br /> <br /> Kandice Tanner<br /> Tissue Morphodynamics Unit, Laboratory for Cell Biology,<br /> Center for Cancer Research, National Cancer Institute, <br /> National Institutes of Health<br /> <br /> Metastasis to distant organs remains the lethal outcome in most malignant tumors. The role of the microenvironment is emerging as critical for malignant progression, metastasis and tumor etiology. Specifically, the interactions between tumor cells and the extracellular matrix (ECM), normal cells and immune cells are critical to establish the metastatic niche. Our goal is to dissect the universal physical attributes that a tumor cell must possess to successfully colonize a foreign organ. Namely the cell must be able to invade, adhere and proliferate while evading the immune system. To address these questions, we use biophysical tools to measure forces that cells use to actively remodel and create the microenvironmental niche using 3D cell culture models for metastasis and similar assays in zebrafish. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105997&date=2017-04-05 Stereotype Threat and Identity Threat: The Science of A Diverse Community, Apr 5 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108106&date=2017-04-05 Please join us for an important discussion on Stereotype and Identity Threat led by Professor Claude Steele of Psychology, followed by a panel discussion with Professor Waldo Martin, Jr. of American History and Citizenship and Professor Eva Nogales of Biochemistry, Biophysics and Structural Biology.<br /> <br /> This event is sponsored by the Division of Biological Sciences, who welcomes the campus community at large to attend. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108106&date=2017-04-05 Neuroscience Student Seminar Series, Apr 6 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=102370&date=2017-04-06 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=102370&date=2017-04-06 Biomimetic Engineering of Squid Sucker Ring Teeth Proteins: From Biology to Technology, Apr 7 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105966&date=2017-04-07 Living organisms are “green chemist” masters, producing multi-functional materials under benign environmental conditions, with a limited amount of building blocks. Thus, they constitute important biomimetic model systems for eco-friendly and multi-scale processing of materials.<br /> <br /> Proteins constitute either the structural components of biological materials or the templates that control the growth and self-assembly of inorganic components into complex hierarchical biocomposites.<br /> <br /> In this talk, our pioneer efforts in establishing Next-Generation sequencing (RNA-Seq) in the context of biomimetic materials engineering will be described. I will specifically illustrate our efforts in deploying this platform towards the intriguing squid Sucker Ring Teeth (SRT), which are remarkable protein-based materials that can compete with the best structural synthetic polymers in terms of mechanical performance. Despite these unusual properties, inter-chain chemical crosslinking is absent and the teeth are fully stabilized by a network of hydrogen bonds. We have shown that SRT are entirely made of modular “suckerin” proteins, which assemble into a supramolecular network reinforced by nano-confined β-sheets. Because of their supra-molecular assembly, SRTs exhibit thermoplastic properties (an unusual feature for a protein-based material), which can be exploited to re-process and mold the proteins into complex shapes by simple lithographic techniques and make SRT a promising material as “bio-ink” for 3D bioprinting. <br /> <br /> We have also established recombinant expression systems that allow us to readily express full-length suckerins in large quantities. The specific molecular architecture of suckerins can be exploited to prepare biomaterials spanning 7-orders of magnitude of elasticity, from soft gels matching the elasticity of liver to stiff films with a Young’s modulus approaching that of bone. The ease of processability and redox activity of suckerins can also be used to induce the growth of metallic nanoparticles without reducing agents, including from redox-active nano-structured solid substrates.<br /> <br /> I will also describe our recent efforts in engineering suckerins for nanomedicine applications. Suckerins can be prepared into nanoparticles with a controlled particle size in the 100-200 nm size range, and we have successfully used these nanoparticles for efficient drug delivery and gene transfection in vitro and in vivo. Notably, suckerin nanoparticles are able to encapsulate hydrophobic drugs for pH-dependent release in vitro, and can also effectively inhibit tumor growth in vivo. Suckerins can also complex and stabilize plasmid DNA, with the complexes stabilized by hydrophobic interactions of the β-sheet domains as opposed to electrostatic interactions commonly achieved with cationic polymers, thus lowering cytotoxicity traditionally associated with such polymers.<br /> *****<br /> Prof. Miserez did his PhD in MSE at EPFL, a post-doc at UC Santa Barbara, and joined NTU in 2009. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105966&date=2017-04-07 Making sense of intrinsically disordered proteins, Apr 10 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105220&date=2017-04-10 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105220&date=2017-04-10 Chiron Lecture, Apr 11 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=89546&date=2017-04-11 Chiron Lectures<br /> This seminar is partially sponsored by NIH http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=89546&date=2017-04-11 Plant and Microbial Biology Plant Seminar: "Probing Hidden Genetics in Dynamic Signaling Networks", Apr 12 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105143&date=2017-04-12 We are probing plant life by developing simple and powerful tools and strategies to unravel plant signal transduction pathways extending from sensors/receptors to signaling cascades and target genes and proteins that are central to energy and metabolic homeostasis, innate immunity, stress adaptation, cell fate specification, plant shape and architecture determination. Our investigations are guided by our curiosity and the desire to promote the use of green plants as a versatile and fascinating model system for discovering fundamental principles in the regulatory networks of living organisms. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105143&date=2017-04-12 BioE Seminar: “Developing new microfluidic technologies for high-throughput biophysical measurements of molecular interactions”, Apr 12 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105998&date=2017-04-12 Spring 2017 Seminar Series<br /> <br /> Wednesday, April 12<br /> 12noon - 1:00pm<br /> 290 Hearst Mining Building<br /> <br /> “Developing new microfluidic technologies for high-throughput biophysical measurements of molecular interactions” <br /> <br /> Polly Fordyce<br /> Assistant Professor of Genetics and Bioengineering<br /> Fellow, ChEM-H Institute<br /> Stanford University<br /> <br /> Recent technological advances have led to an explosion in our knowledge of the macromolecular parts that exist within cells. The next great biological challenge lies in making quantitative measurements of the interactions between them and developing biophysical models that allow us to predict their cellular consequences. To address this, we have developed two new microfluidic tools that retain the quantitative aspects of traditional, one-at-a-time measurements while dramatically increasing their throughput. The first tool (MITOMI) consists of a microfluidic platform that enables quantitative measurement of binding affinities and kinetics for up to 4,000 interactions in parallel. We are currently combining this platform with deep sequencing to understand how transcription factors find their genomic targets, and adapting it for high-throughput enzymology measurements with the goal of improving enzyme design. The second tool is a microfluidic platform for producing spectrally encoded beads with an extremely large potential coding space, which we are currently using to understand how proteins involved in cell signaling find their target substrates. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105998&date=2017-04-12 Chiron Lecture, Apr 12 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=89547&date=2017-04-12 Chiron Lectures<br /> This seminar is partially sponsored by NIH http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=89547&date=2017-04-12 Nature's gift: How microbial protein structure-function discoveries illuminate the circuitry of adaptive and maladaptive behavior, Apr 13 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=102371&date=2017-04-13 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=102371&date=2017-04-13 Insights into Industry, Apr 14 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108386&date=2017-04-14 Keynote Speaker: Wendy Young, VP of Discovery Chemistry, Genentech<br /> <br /> Panelists from Dow, Clorox, Sandia National Lab, <br /> Merck, Caribou Biosciences, Applied Molecular Transport<br /> <br /> Join UC Berkeley SLAM for a unique opportunity to learn about research and development (R&D) in all sizes and forms. Chat with our panelists and speakers from a variety of backgrounds during lunch and throughout the event.<br /> <br /> Science and engineering graduate students, post-docs, and visiting scholars who are interested in a career in R&D are strongly encouraged to attend. Registration is on a first-come, first-serve basis and includes breakfast, lunch and refreshments.<br /> <br /> Register <a href="https://www.eventbrite.com/e/insights-into-industry-registration-33067495770?mc_cid=ed3bc4706b&mc_eid=[UNIQID]">here</a>. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108386&date=2017-04-14 Exploring the Interfaces Between Silicon and Soft Materials, Apr 14 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105988&date=2017-04-14 Soft materials are complex, with unique characteristics and functionalities spanning multiple length scales. Silicon-based materials are typically rigid and their direct interfaces with soft materials still represent an area with many open questions and unknown opportunities. <br /> <br /> To enable new studies at these interfaces, it is important to target the right organizational length scale. For example, in the case of sub-cellular organization, this length scale is on the order of tens to hundreds of nanometers. <br /> <br /> In this talk, I will present several soft material-enabled exploratory approaches for the syntheses and applications of nanostructured silicon. Some of these silicon materials are deformable and have been tested with extra- and intracellular components (i.e., extracellular matrix, cytoskeleton and phospholipid bilayer) with an initial emphasis on biomechanics and bioelectrics. In addition to providing new knowledge of nanoscale silicon-based chemistry, these studies will deepen our understanding of the fundamental limits of physical and biological signal transduction between subcellular components and synthetic systems. <br /> <br /> At the end of my talk, I will discuss future opportunities in materials chemistry toward seamless silicon-based biointegration.<br /> <br /> ***<br /> Bozhi Tian did his Ph.D. at Harvard with Charles Lieber on new nanowire materials synthesis, the fundamental study of high performance nanowire photovoltaics and the application of novel nanowire devices in cells and tissue. He worked with Robert Langer and Daniel Kohane as a postdoc in tissue engineering. He is now an assistant professor at the Univ of Chicago, working on semiconductor-based cellular biophysics. Dr. Tian’s accolades from his independent career include the PECASE, 2016 NIH new innovator award, 2016 ONR young investigator award, 2016 Sloan fellowship, 2015 AFOSR young investigator award, 2013 NSF CAREER award, 2013 Searle Scholar award, and 2012 TR35 honoree. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105988&date=2017-04-14 Rubber vs. Silly Putty: Extracellular matrix viscoelasticity and its impact on cells, Apr 14 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108604&date=2017-04-14 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108604&date=2017-04-14 Earl L. Muetterties Memorial Lecture, Apr 14 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=104925&date=2017-04-14 The first lecture (April 7th) highlighted the opportunities that computation offers to accelerate the discovery of new extended solid materials. These approaches are centred on the crystal structures of the materials. Traditionally, we think about the structure of a solid in terms of the unit cell of the material derived from Bragg diffraction, but this involves averaging out local deviations such as short-range order, defects and dynamical behaviour. These deviations from the average structure are often decisive in determining the properties of the material, for example as an electrode or a catalyst. I will discuss how design that takes these non-average features into account can access important properties and interesting behaviour.<br /> <br /> While the average structure computationally-enabled approach of the first lecture attained the difficult goal of combining polar and ferromagnetic ground states at room temperature in a single phase, the resulting material did not allow switching of the electrical polarisation, and thus did not afford the multiferroic needed for next-generation information storage. I will describe a non-computational strategy based on local structure information that produces a magnetoelectric multiferroic material able to switch both of these long-range orders at room temperature (1). The role of local chemistry in driving this “real structure” design emphasises the enduring importance of developing the chemical understanding that underpins “classical” approaches to materials design.<br /> <br /> Synthesis of materials containing multiple distinct phases overcomes further limitations of the single phase average structure approach, and requires working outside the average structure. Using simple design ideas, we have controlled the structure of an oxide beyond the unit cell length scale by the chemical bonding-driven self-organisation during synthesis of two structurally-related phases over nanometre distances. The two phases have distinct functions that give the resulting chemically-controlled composite excellent performance as an intermediate temperature solid oxide fuel cell cathode (2). In particular, dynamic compositional exchange across the interfaces between the two phases allows the material to repair itself and remain stable under the operating conditions.<br /> <br /> Dynamical processes are key to the function of proteins, and one of our longstanding research goals is to produce metal-organic frameworks with responses that are governed by the dynamics of the molecules that constitute them. By engineering weak interactions we can chemically control the structures adopted in response to guests, and exploit the porosity for recognition of complex molecules (3).<br /> <br /> (1) P. Mandal et al., Nature 525, 363, 2015<br /> (2) J.F. Shin et al., Nature Energy 2, 16214, 2017<br /> (3) C. Marti-Gastaldo et al., Nature Chemistry 6, 343, 2014; J. Am. Chem. Soc. 2017 accepted http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=104925&date=2017-04-14 Bristol-Myers Squibb Lecture, Apr 18 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=104945&date=2017-04-18 The ultimate goal of our research group is to develop “problem-solving” innovative functional molecules that make a marked change in the form and nature of science and technology. During the last 10 years in Nagoya, we have pioneered an increasingly general synthesis platform for a range of functional molecules including molecular nanocarbons, π-conjugated organic materials, pharmaceuticals, and small molecules for plant biology and chronobiology. The uniqueness of our approach can be seen from the fact that most of the functional molecules that we have created were rapidly synthesized or discovered by our unique and powerful C-H activation catalysts and reactions. In this talk, I will introduce the most recent exciting discoveries from our laboratories. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=104945&date=2017-04-18 BioE Seminar: “Epigenetics and Evolution in the Age of Synthetic Biology”, Apr 19 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105999&date=2017-04-19 Spring 2017 Seminar Series<br /> <br /> Wednesday, April 19<br /> 12noon - 1:00pm<br /> 290 Hearst Mining Building<br /> <br /> “Epigenetics and Evolution in the Age of Synthetic Biology”<br /> <br /> Ahmad (Mo) Khalil<br /> Innovation Career Development Assistant Professor, Department of Biomedical Engineering<br /> Associate Director, Biological Design Center<br /> Boston University<br /> <br /> Visiting Scholar, Wyss Institute for Biologically Inspired Engineering<br /> Harvard University<br /> <br /> <br /> Cells use genetically-encoded molecular networks to sense and respond to the changing environment. Our lab uses synthetic biology to study the function of these cellular networks, and to predictively engineer them for useful applications. While the synthetic approach has been used to explore a wide range of cellular functions, less has been done on the systems involved in establishing and interfacing with epigenetic processes. In this talk, I will discuss our efforts to apply synthetic biology to engineer epigenetic systems, which are important for expanding the repertoire of cellular responses and establishing the distinct cellular identities that make up multicellular organisms. Specifically, I will discuss the development of synthetic tools and systems for controlling: (1) molecular signatures and changes to chromatin to produce/program distinct gene expression outputs; and (2) an altogether different form of epigenetics, encoded in the self-propagating conformations of prion proteins. A broad goal of this work is quantitatively defining/controlling the molecular properties that underlie cellular responses via engineering. A newer, complementary goal in the lab is using engineering to quantitatively control environmental and selective conditions that can be imposed on organisms in the laboratory. I will discuss these new high-throughput technologies, and show how they can be applied to comprehensively map adaptive cellular phenotypes and evolve new biological functions. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105999&date=2017-04-19 The Annual Alexander Pines Lecture, Apr 25 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=104505&date=2017-04-25 Interest in the phenomenon of amyloid formation by peptides and proteins has developed with extraordinary rapidity in recent years, such that is now a major topic of research across a wide range of disciplines. The reasons for this surge of interest arise both from the links between amyloid formation and a range of rapidly proliferating medical disorders, including Alzheimer’s and Parkinson’s diseases, and from the insights that an understanding of the amyloid state can provide about the nature of the biologically functional forms of proteins. Recent progress in understanding the factors affecting the stability of the amyloid state relative to that of the native state of a protein, along with the development of methods for defining the mechanism of the conversion between the different states, has led to a detailed understanding of the links between protein aggregation, amyloid formation and human disease. This talk will give an overview of recent advances in this field of study and discuss recent progress towards understanding the structural and physical properties of the amyloid state, the kinetics and mechanism of its formation, and the nature and origins of its links with pathogenesis. In addition, the talk will discuss the ways in which protein aggregation and amyloid formation may be inhibited or suppressed, both to understand the nature of protein homeostasis in naturally functioning organisms and also to address the development of therapeutic strategies through which to combat the loss of homeostasis and the onset and progression of disease. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=104505&date=2017-04-25 Plant and Microbial Biology Plant Seminar: "Plant gene regulation and complex traits genetics", Apr 26 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105131&date=2017-04-26 Our research focuses on two related fields: the genetic architecture of complex traits and the role of gene regulation and protein folding in generating heritable phenotypic variation. We advance complex trait genetics by ascertaining uncharacterized sequence variation and by resolving the relative importance of additive variation and epistasis in complex traits. Lastly, to improve the genotype- phenotype map, we envision molecular markers, applicable in any organism, that predict the penetrance of genetic variants in a given individual. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105131&date=2017-04-26 BioE Seminar: “Molecular Engineering of Biologic Drug Therapies and Diagnostic Platforms”, Apr 26 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106000&date=2017-04-26 Spring 2017 Seminar Series<br /> <br /> Wednesday, April 26<br /> 12noon - 1:00pm<br /> 290 Hearst Mining Building<br /> <br /> “Molecular Engineering of Biologic Drug Therapies and Diagnostic Platforms”<br /> <br /> Patrick Stayton<br /> Distinguished Career Professor, Department of Bioengineering<br /> Director, Molecular Engineering & Sciences Institute<br /> University of Washington<br /> <br /> Biologic drug therapies based on proteins, RNA, DNA and engineered cells have the broad target range that could translate the potential of the Genome Era into impactful new classes of therapeutics and Individualized Medicines. Today, however, biologic drug therapies are often limited by delivery and manufacturing barriers. We have been developing polymeric drug carriers and cell manufacturing systems that enable new approaches to biologic therapies. These platforms also provide opportunities for small molecule therapies and biomarker/diagnostic profiling. The delivery systems for proteins and nucleic acids mimic the highly efficient intracellular delivery systems found in pathogenic viruses and organisms. The carriers are applicable to a wide range of biotherapeutics, and might open up new families of peptide, antibody or nucleic acid drug candidates that attack previously inaccessible intracellular targets. Polymeric materials of a similar class are being developed to improve biomarker and cell isolation technologies, as well as to improve biological manipulation steps necessary to scale and streamline new T-cell and stem cell therapies. This talk will highlight some of the new capabilities of the therapeutic, diagnostic, and cell manufacturing platforms. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106000&date=2017-04-26 Systems Genetics of Tuberculosis , Apr 26 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=100738&date=2017-04-26 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=100738&date=2017-04-26 Center for Computational Biology Seminar, Apr 26 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108270&date=2017-04-26 Title: Tackling world health problems through high-throughput microscopy imaging and analysis<br /> <br /> Abstract:<br /> Images contain rich information about the state of cells, tissues, and organisms. We work with biomedical researchers around the world to extract quantitative information from images, particularly in high-content screening experiments involving physiologically relevant model systems. As the biological systems and phenotypes of interest become more complex, so are the computational approaches needed to properly extract the information of interest; we continue to bridge the gap between biologists’ needs and the latest in computational science (e.g., deep learning). Beyond measuring features that biologists specify, we extract more from images through profiling experiments using the Cell Painting assay, where thousands of morphological features are measured from each cell’s image. We are working to harvest similarities in these “profiles” for grouping genes, identifying the functional impact of cancer-associated alleles, discovering disease-associated phenotypes, and identifying novel therapeutics. Ultimately, we aim to make perturbations in cell morphology as computable as genomics data. All novel algorithms and approaches from our laboratory are released as open-source software, including CellProfiler, CellProfiler Analyst, and cytominer.<br /> <br /> Biography:<br /> Dr. Carpenter has been a Principal Investigator at the Broad Institute of Harvard and MIT since 2007. Carpenter focused on high-throughput image analysis during her postdoctoral fellowship at the Whitehead Institute for Biomedical Research and MIT’s CSAIL (Computer Sciences/Artificial Intelligence Laboratory). Her PhD is in cell biology from the University of Illinois, Urbana-Champaign. Carpenter has been named an NSF CAREER awardee, a Massachusetts Academy of Sciences fellow (its youngest at the time), and a Genome Technology “Rising Young Investigator”. The team’s open-source CellProfiler software is used by thousands of biologists worldwide. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108270&date=2017-04-26 Bridging the gap between the spatial and mnemonic views of the hippocampus, Apr 27 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=102372&date=2017-04-27 This seminar is partially sponsored by NIH http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=102372&date=2017-04-27 18th Microbiology Student Symposium, Apr 29 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107380&date=2017-04-29 The Microbiology Student Group at UC Berkeley invites you to join us at the 18th Annual Microbiology Student Symposium (MSS) on Saturday, April 29, 2017 at the David Brower Center in Berkeley. This year, our keynote speakers are Bonnie Bassler from Princeton and Edward DeLong from University of Hawaii. <br /> <br /> MSS is committed to being a free symposium, so please register now to attend and submit your abstract for talks/poster presentations and/or microbial art. Prizes will be awarded for the best posters, talk, and art! http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107380&date=2017-04-29 Physical Mechanisms of Cell Organization on Micron Length Scales, May 1 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105266&date=2017-05-01 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105266&date=2017-05-01 Innate-like B cells and their rules of engagement in infection, May 2 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108375&date=2017-05-02 This seminar is partially sponsored by NIH http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108375&date=2017-05-02 Deconstructing and reconstructing microbial communities using cheese, May 2 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=101213&date=2017-05-02 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=101213&date=2017-05-02 BioE Seminar: “Biologically fabricated materials composed of engineered biofilm matrix proteins”, May 3 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106001&date=2017-05-03 Spring 2017 Seminar Series<br /> <br /> Wednesday, May 3<br /> 3:00-4:00PM<br /> 290 Hearst Mining Building<br /> <br /> “Biologically fabricated materials composed of engineered biofilm matrix proteins”<br /> <br /> Neel Joshi<br /> Associate Professor of Biological Engineering<br /> Harvard University<br /> School of Engineering and Applied Sciences<br /> Wyss Institute for Biologically Inspired Engineering<br /> <br /> The intersection between synthetic biology and materials science is an underexplored area with great potential to positively affect our daily lives, with applications ranging from manufacturing to medicine. My group is interested in harnessing the biosynthetic potential of microbes, not only as factories for the production of raw materials, but as fabrication plants that can orchestrate the assembly of complex functional materials. We call this approach, “biologically fabricated materials”, a process whose goal is to genetically program microbes to assemble materials from protein-based building blocks without the need for time consuming and expensive purification protocols or specialized equipment. Accordingly, we have developed Biofilm Integrated Nanofiber Display (BIND), which relies on the biologically directed assembly of biofilm matrix proteins of the curli system in E. coli. We demonstrate that bacterial cells can be programmed to synthesize a range of functional materials with straightforward genetic engineering techniques. The resulting materials are highly customizable and easy to fabricate, and we are investigating their use for practical uses ranging from bioremediation to engineered therapeutic probiotics. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106001&date=2017-05-03 IB Seminar: Disease transmission through the lens of fluid dynamics, May 4 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107135&date=2017-05-04 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107135&date=2017-05-04 Sculpting the nervous system: Cellular and molecular mechanismsof neural circuit refinement, May 4 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=102373&date=2017-05-04 This seminar is partially sponsored by NIH http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=102373&date=2017-05-04 Department of Molecular and Cell Biology Annual Alumni Seminar: Structure and strategy in host-pathogen conflicts, May 5 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108589&date=2017-05-05 Department of Molecular & Cell Biology Annual Alumni Seminar<br /> http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108589&date=2017-05-05 Scientific Writing, May 11 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107500&date=2017-05-11 Clear writing is a valuable skill for all researchers, and it can positively influence the impact of your science. This workshop will help you write about your research more clearly and effectively. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107500&date=2017-05-11 QB3 Postdoc Seminar, May 12 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109129&date=2017-05-12 Speaker 1: Charles Hespen (Michael Marletta lab)<br /> <br /> Probing the function of the glycine hinge in H-NOX signaling <br /> <br /> Abstract<br /> Acute and specific sensing of diatomic gas molecules is an essential facet of biological signaling. Heme-Nitric oxide/Oxygen sensing (H-NOX) proteins are a family of nitric oxide (NO) sensors found in diverse classes of bacteria and eukaryotes. Upon binding of NO, H-NOX proteins undergo a conformational change, which regulates the activity of a cognate effector domain. Two conserved glycine residues (G71 and G143) form the crux of this shift and are conserved in nearly all H-NOX proteins. In multiple H-NOX structures, this flexible “glycine hinge” appears essential for the conformational shift in response to ligand binding. Introduction of steric bulk in the form of an alanine substitution at one of the glycine hinge residues would likely lock the H-NOX in one conformational state and disrupt NO signaling. Although G71 and G143 are mostly conserved, a small group of H-NOX domains encoded in species from the family Flavobacteriaceae have a single alanine substitution (A71) in the glycine hinge region. To understand the effects of this native alanine substitution, the H-NOX protein from Kordia algicida was characterized.<br /> <br /> <br /> Speaker 2: Travis Del Bonis-O’Donnell (Markita Landry lab)<br /> <br /> Dual near infrared excitation-emission two-photon microscopy for deep-tissue dopamine nanosensor imaging<br /> <br /> Abstract <br /> Neuromodulatory neurotransmitters in the brain are implicated in a wide variety of psychiatric and neurological disorders, yet their quantification in the biologically-relevant milieu of the living brain remains inaccessible. Non-invasive, optical methods to directly quantify neurotransmission will transform our ability to study and understand psychiatric disorders. Recently, functionalized single walled carbon nanotubes (SWNTs) have emerged as promising near-infrared (NIR) fluorescent nanosensors for the sensitive and rapid detection of neurotransmitter dopamine. These sensors fluorescence in the NIR-II window (1000-1700 nm) where absorption and scattering of light is minimal, making them optimally suited for non-invasive imaging in brain tissue. However, the photoexcitation of SWNT dopamine nanosenors is currently accomplished with highly-scattering visible light. To further optimize dopamine nanosensors for in vivo imaging, we show that non-linear photoexcitation of our SWNT nanosensors can be achieved using a 1560 nm laser excitation source, falling within the optimal NIR-II window. Using a femtosecond pulsed erbium laser, we observe two-photon induced fluorescence of SWNT dopamine nanosensors and measure nanosensor quantum yield and 2-photon cross sections. Furthermore, we demonstrate SWNT-based molecular recognition of dopamine using two-photon excitation, confirming that the molecular recognition principle of our sensors is compatible with non-linear excitation. Finally, we show significantly improved fluorescence spatial resolution attained by two-photon excitation when imaging in strongly scattering tissue phantoms, motivating future work using these sensors for in vivo, real-time sensing of dopamine in brain tissue. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109129&date=2017-05-12 Behavioural Signatures of Ganglion Cell Dysfunction in Glaucoma, May 15 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109153&date=2017-05-15 ​It is well established that retinal ganglion cells die in glaucoma. What is less clear is whether glaucoma induces a protracted period of dysfunction prior to cell death. This talk will review the strengths and limitations of some of the behavioural evidence that has been used to argue for the presence of dysfunctional retinal ganglion cells in glaucoma. Establishing that such dysfunction exists creates the possibility that future therapies could rescue these cells, thereby partly restoring visual function. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109153&date=2017-05-15 Understanding and overcoming drug resistance in cancer, May 16 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108792&date=2017-05-16 This seminar is partially sponsored by NIH http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108792&date=2017-05-16 Genetically encoded tools for manipulation of metabolism in living cells, May 16 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109159&date=2017-05-16 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109159&date=2017-05-16 Proposal Development Consultations, May 18 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107502&date=2017-05-18 Bring your questions, ideas, and proposal drafts to an open consultation session with the Berkeley Research Development Office. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107502&date=2017-05-18 CryoEM snapshots of the spliceosome at work: Insights into its Catalytic Mechanism, May 22 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108590&date=2017-05-22 This seminar is partially sponsored by NIH http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108590&date=2017-05-22 Interferon-inducible GTPases in host resistance and inflammation, May 23 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108982&date=2017-05-23 This seminar is partially sponsored by NIH http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108982&date=2017-05-23 The Role of Astrocytes in Neurovascular Coupling at the Capillary and Arteriole Level in the Retina and Brain, May 23 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=100335&date=2017-05-23 Neuronal activity evokes a spatially and temporally localized increase in blood flow to power the information processing carried out by the neurons, a phenomenon that underlies BOLD fMRI signals. This neurovascular coupling occurs both in the brain and the retina.<br /> <br /> In the retina, both light- and glial-stimulation evoke pronounced arteriole dilations (30.8±3.7% and 23.5±4.1%, respectively). This dilation depends on O2: high O2 inhibits dilation and promotes constriction. Retinal neurovascular coupling is decreased in diabetic patients, and I found that this deficit (~60%) can also be detected in an animal model of diabetes before any overt loss of neuronal function. These retinas displayed signs of glial reactivity and an upregulation of inducible nitric oxide synthase (iNOS). Inhibiting iNOS function in diabetic retinas restored normal neurovascular coupling both in vitro and in vivo.<br /> <br /> In the cerebral cortex, neuronal activity dilates arterioles and capillaries via two separate signaling pathways. Neuronal activity in cortical slices evoked a capillary dilation of 14.7±0.5% and an arteriole dilation of 7.1±0.7%. Stimulation-evoked capillary dilation was reduced by 64% when [Ca2+]i in nearby astrocytes was buffered, but arteriole dilations were unchanged. Capillary dilation was dependent on the ATP-gated ion channel P2X1 and subsequent synthesis and release of vasoactive prostaglandin E2. Arteriole dilation, on the other hand, depended upon NMDA receptor driven production of nitric oxide.<br /> <br /> These findings reveal a novel dichotomy in the molecular and cellular signaling cascades that regulate CNS blood flow in different vascular compartments, provide insight into the mechanisms underlying the BOLD signal, and demonstrate how disease-induced alterations of NO signaling can alter blood flow. Furthermore, they suggest that restoring neurovascular coupling, which is altered in many CNS disorders, could provide novel therapeutic targets. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=100335&date=2017-05-23 EHS 201 Biosafety in Laboratories, May 25 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105091&date=2017-05-25 This training is required for anyone who is listed on a Biological Use Authorization (BUA) application form that is reviewed by the Committee for Laboratory and Environmental Biosafety (CLEB). A BUA is required for anyone working with recombinant DNA molecules, human clinical specimens or agents that may infect humans, plants or animals. This safety training will discuss the biosafety risk assessment process and the means to mitigate those risks such as good work practices and personal protective equipment. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=105091&date=2017-05-25 Neural circuits for goal-directed sensorimotor transformation, May 30 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108299&date=2017-05-30 A key function of the brain is to interpret incoming sensory information in the context of learned associations in order to guide adaptive behavior. However, the precise neuronal circuits and causal mechanisms underlying goal-directed sensorimotor transformations remain to be clearly defined for the mammalian brain. Technological advances in mouse genetics to define cell-types, in optogenetics to control neuronal activity, and in electrophysiological and imaging techniques to precisely measure neuronal activity now begin to make it possible to obtain a detailed mechanistic understanding of the neuronal circuits driving learned goal-directed sensorimotor transformations. Here, I will discuss my laboratory’s efforts to characterize a simple whisker-cued operant behavior. Although we are very far from a complete understanding, we find evidence for cell-type specific contributions of different neurons in both neocortex and striatum, which are likely to participate causally in both learning and execution of this reward-motivated sensorimotor task. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108299&date=2017-05-30 Sculpted Light in the Brain, Jun 9 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108202&date=2017-06-09 “Sculpted Light in the Brain” is a one-day conference and workshop aimed at fostering collaborations between neuroscientists, computer scientists, optics researchers, and other scientists who share the common interest of developing better technology to observe and control neural activity in the awake, behaving brain. “Sculpted Light” refers to a broad class of methods where light is shaped to probe neural function.<br /> This meeting aims to promote future collaboration opportunities by gathering established scientists and the next generation of researchers from these fields to discuss future technologies that will enable real time optical communication with the living brain. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108202&date=2017-06-09 Sculpted Light in The Brain, Jun 9 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108688&date=2017-06-09 Sculpted Light in the Brain is a one-day conference and workshop aimed at fostering collaborations between neuroscientists, computer scientists, optics researchers, and other scientists who share the interest of developing better technology to observe and control neural activity in the awake, behaving brain.<br /> <br /> Register <a href="http://www.slb2017.com/registration/">here</a>. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108688&date=2017-06-09 Cellular Biophysics: Experiment Meets Theory, Jun 10 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108689&date=2017-06-10 Bringing together the cell biology, bioengineering and physics communities interested in the theoretical and experimental approaches to understanding cellular processes including: cellular membranes, the cytoskeleton, interactions between macromolecules in cells, and cell-cell and cell-substrate interactions.<br /> <br /> Register <a href="https://www.eventbrite.com/e/cellular-biophysics-experiment-meets-theory-registration-33436194558">here</a>. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108689&date=2017-06-10 Photosynthesis, Carbon Fixation and the Environment, Jun 14 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108690&date=2017-06-14 Oxygenic photosynthesis is the most important biological process in the history of Earth and the major process removing greenhouse gases from the atmosphere. Join us to share your photosynthesis-related research and learn about the diverse photosynthesis research going on at Berkeley.<br /> <br /> Register <a href="https://www.eventbrite.com/e/photosynthesis-carbon-fixation-the-environment-registration-33436242702">here</a>. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108690&date=2017-06-14 Bay Area Stress and Chaperone, Jun 23 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108691&date=2017-06-23 Highlighting the most recent advances in stress and chaperone biology being explored at Berkeley and the Bay Area’s exceptional scientific community, the symposium will focus on current approaches as well as the latest experiments in stress and chaperone biology and to establish interdisciplinary collaborations.<br /> <br /> Register <a href="https://www.eventbrite.com/e/bay-area-stress-chaperone-symposium-registration-33436258750">here</a>. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108691&date=2017-06-23 Biophysics of Nuclear Organization and Function, Jul 8 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108692&date=2017-07-08 Understanding the biophysical properties of the nucleus is an exciting emerging field, the advancement of which is highly dependent on cross-disciplinary research. This one-day symposium is aimed at uniting Berkeley researchers with a shared interest in the role of biophysics in chromatin structure and function.<br /> <br /> Register <a href="https://www.eventbrite.com/e/biophysics-of-nuclear-organization-function-registration-33436287837">here</a>. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=108692&date=2017-07-08 Re-writing Genomes: A New Era in Genome Engineering, Aug 18 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109149&date=2017-08-18 In this fifth annual event, leading experts in genomics and molecular biology will explore how genome editing technologies are transforming basic research and biomedical engineering. The event is free and open to the public, but space is limited.<br /> <br /> <a href="https://docs.google.com/a/berkeley.edu/forms/d/e/1FAIpQLSdQWq96WGIHZAitLC7HZFSzD4E6wxuHV-o5k8CtykGOFS79fQ/viewform">Click here to add your email address to the event mailing list</a> -- we'll send you a message when registration opens in July.<br /> <br /> (NOTE: INCLUSION ON THIS LIST IS NOT THE SAME AS EVENT REGISTRATION. YOU MUST STILL REGISTER FOR THE SYMPOSIUM ONCE REGISTRATION OPENS.)<br /> <br /> Organizers<br /> Dirk Hockemeyer, UC Berkeley<br /> Jennifer Doudna, UC Berkeley, HHMI<br /> <br /> Confirmed speakers<br /> Andrea Crisanti, Imperial College London<br /> Jennifer Doudna, UC Berkeley, HHMI<br /> David Fidock, Columbia University Medical Center<br /> Dirk Hockemeyer, UC Berkeley<br /> J. Keith Joung, Massachusetts General Hospital<br /> Joshua Modell, The Rockefeller University<br /> Eric Olson, University of Texas<br /> Leslie Vosshall, The Rockefeller University<br /> Mark Walters, UCSF/Oakland Children's Hospital<br /> Blake Wiedenheft, Montana State University http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109149&date=2017-08-18 Plant and Microbial Biology Plant Seminar, Aug 30 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109180&date=2017-08-30 A variety of viruses infect the human nervous system, often with severe consequences. While vaccines have largely defeated the paralysis caused by polio, other viruses such as rabies, West Nile virus, and herpes simplex virus (HSV) continue to cause neurological infections that require clinical intervention. More than 70% of adults in the United States carry HSV, whether they know it or not. HSV causes recurrent genital and oral lesions (e.g. cold sores), and in rare cases can progress to cause potentially fatal brain infections. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109180&date=2017-08-30 Plant and Microbial Biology Plant Seminar, Sep 6 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109182&date=2017-09-06 We study epigenetics using plants as model systems. Our goals are to understand how the epigenome contributes to basic cellular mechanisms like DNA replication and gene silencing, and also complex processes like developmental transitions, trans-generational inheritance and aging. We are also interested in exploring how the epigenome can be modulated to improve current genome engineering technologies in animals and plants. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109182&date=2017-09-06 Plant and Microbial Biology Plant Seminar, Sep 13 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109181&date=2017-09-13 Research in our laboratory focuses on two aspects of DNA virus biology: 1) The role of the host translation system during infection by poxviruses. 2) Microtubule regulation and function during herpes simplex virus infection. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109181&date=2017-09-13 Plant and Microbial Biology Plant Seminar, Sep 20 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109183&date=2017-09-20 Our laboratory focuses on the role that microbial communities play in human homeostasis, health and disease. We firmly believe that the various microbial components of human ecosystems including bacteria, viruses, archaea, and fungi are important factors that help determine the natural history of their hosts. Furthermore, their interactions with humans or their interactions with other microbial constituents in these communities likely have consequences for human health. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109183&date=2017-09-20 Plant and Microbial Biology Plant Seminar, Sep 27 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109184&date=2017-09-27 The Torii lab studies how plant cells coordinate proliferation and differentiation during organ morphogenesis to generate beautiful, orderly patterns. We aim to understand the molecular and genetic bases of cell-cell communication that specifies organ size, shape, and stomatal patterning through integrated approaches. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109184&date=2017-09-27 Plant and Microbial Biology Plant Seminar, Oct 4 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109185&date=2017-10-04 Understanding biodiversity requires more than identifying the number of species on earth. We must also elucidate how species interactions govern the dynamics of communities, ecosystems, and species diversity. My lab uses a broad combination of approaches including experimental ecology, field observations, molecular phylogenetics, and population genetics to understand the role that interspecific interactions play in creating diversity. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109185&date=2017-10-04 Plant and Microbial Biology Plant Seminar, Oct 11 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109186&date=2017-10-11 The Montgomery Lab pursues a common research theme of understanding how individuals perceive, respond to, and are impacted by the environments in which they exist. Primary research efforts of the group are focused on the responses of photosynthetic organisms to external light cues. Additionally, Montgomery pursues this theme in the context of effective mentoring in research environments. http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109186&date=2017-10-11 Plant and Microbial Biology Plant Seminar, Oct 18 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109187&date=2017-10-18 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=109187&date=2017-10-18 Choreography of bacterial nanomotors revealed by live-cell imaging, Oct 25 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106274&date=2017-10-25 Roger Y. Stanier Memorial Lecture<br /> http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=106274&date=2017-10-25 Structural and Quantitative Biology Seminar-template, Nov 4 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=56724&date=2017-11-04 Coffee & Refreshments served on lower level Stanley Hall @3:50pm-4:10pm http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=56724&date=2017-11-04 Department of Molecular and Cell Biology Annual Capstone Lecture, Dec 8 http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107710&date=2017-12-08 Department of Molecular & Cell Biology Annual Capstone Lecture<br /> http://events.berkeley.edu/index.php/calendar/sn/qb3.html?event_ID=107710&date=2017-12-08