Molecular and Cell Biology Upcoming Events Autocatalytic backbone α-N-methylation of a fungal enzyme generates a novel family of ribosomally-encoded cyclic anti-nematode peptides, Mar 20 Ion Channels in the Tubulovesicles , Mar 20 From cold sores to encephalitis: herpesvirus invasion of the nervous system, Mar 21 This seminar is partially sponsored by NIH Marian E. Koshland Memorial Lecture: Water bears: Probing how animal body plans evolve and how biological materials can survive extremes, Mar 21 Plant and Microbial Biology Micro Seminar: "When is a fungus not a fungus?", Mar 22 The primary focus of my research is to determine the evolutionary relationships of the eukaryotes and the cellular and genomic innovations associated with the emergence and diversification of the eukaryotic cell. CRISPR-Cas9 gene editing, from mechanism to therapy, Mar 22 CANCELED: Neuroscience Student Seminar Series, Mar 23 Let's Have an Awesome Time Doing Science!, Mar 29 CEND 9th Annual Symposium, Mar 31 Emerging and neglected diseases are a group of debilitating and often deadly infections. As a group, these diseases are poorly understood and generally lack effective tools for prevention, control, and treatment. CEND Annual Symposium aims to strengthen connections between San Francisco Bay Area scientists working on infectious diseases of global health importance and the broader global health research, product development, and advocacy communities. The symposium features a dynamic list of invited speakers from around the world, including scientists from developing countries. Each March the event attracts over 400 registrants. Participants include academic researchers from UC Berkeley, UCSF, Stanford, UC Davis as well as representatives from local biotechnology and pharmaceutical companies and global health nonprofits. Cynthia A. Chan Memorial Lecture: Molecular Machines that Build Membranes, Apr 3 Cynthia A. Chan Memorial Lecture<br /> Nonclassical antigen presentation and T cell recognition, Apr 4 This seminar is partially sponsored by NIH Plant and Microbial Biology Micro Seminar: "The ancestral human microbiome: the evolution and ecology of our microbial self", Apr 5 I am interested in evolutionary medicine and how understanding the ways in which humans have co-evolved with environments, diets, and pathogens allows us to better understand health and disease. My research draws on the methods and theoretical frameworks of several fields, including: molecular biology, archaeology, archaeogenetics (ancient DNA), stable isotope-based paleodietary and paleomigratory analysis, archaeobotany, and zooarchaeology. Links to open-access PDFs of my publications can be found on my and ResearchGate profiles. Stereotype Threat and Identity Threat: The Science of A Diverse Community, Apr 5 Please join us for an important discussion on Stereotype and Identity Threat led by Professor Claude Steele of Psychology, followed by a panel discussion with Professor Waldo Martin, Jr. of American History and Citizenship and Professor Eva Nogales of Biochemistry, Biophysics and Structural Biology.<br /> <br /> This event is sponsored by the Division of Biological Sciences, who welcomes the campus community at large to attend. Neuroscience Student Seminar Series, Apr 6 Targeting Brain Oscillations: Probing Function and Treating Disease?, Apr 6 Making sense of intrinsically disordered proteins, Apr 10 Chiron Lecture, Apr 11 Chiron Lectures<br /> This seminar is partially sponsored by NIH Chiron Lecture, Apr 12 Chiron Lectures<br /> This seminar is partially sponsored by NIH Nature's gift: How microbial protein structure-function discoveries illuminate the circuitry of adaptive and maladaptive behavior, Apr 13 MCB Postdoc Lunch Club, Apr 14 Spring Honors Poster Session, Apr 14 “Visualizing the future of cell biology with cutting-edge electron microscopy”, Apr 14 “Electron Microscopy: A New Old Tool to Support Biological Research”, Apr 17 BBS Honors Symposium, Apr 17 This seminar is partially sponsored by NIH IandP Honors Symposium, Apr 18 This seminar is partially sponsored by NIH CDB Honors Symposium, Apr 19 This seminar is partially sponsored by NIH GGD Honors Symposium, Apr 19 This seminar is partially sponsored by NIH NEURO Honors Symposium, Apr 20 This seminar is partially sponsored by NIH Joint Physics and MCB Colloquium: "SOFT MATTER-BASED SCALING IN MATRIX and NUCLEAR BIOLOGY", Apr 24 Scaling concepts have been successfully applied for many years to synthetic polymers, but application to biology seems under-studied even though cells and tissues are built from polymers. Tissues such as brain and fat are very soft while tissues such as muscle and bone are stiff or even rigid, but the effects on cells are just now being discovered. Having shown that matrix stiffness helps specify tissue lineages in vitro, we used mass spectrometry to quantify protein levels in embryonic, mature, and cancerous tissues and studied tissues as well as cells on gels while tuning stiffness. Extracellular collagen polymers directly determine tissue stiffness with near-classical scaling, and for embryonic heart, contractile beating of the organ and of isolated cells on gels is maximal when the stiffness is that of the normal tissue, consistent with a ‘use it or lose it’ mechanism. Acto-myosin assembly likewise increases with stiffness and stresses the nucleus, which upregulates a nuclear structure protein called lamin-A (related to keratin in fingernails) that again scales with stiffness via ‘use it or lose it’. Lamin-A assembly has evolved to control nuclear plasticity and is known to vary widely between tissues and diseases including cancer. Differentiation of various stem cell types is generally modulated by lamin-A levels downstream of matrix stiffness, with various pathways co-regulated by lamin-A. Complementary insights from cell migration are obtained for DNA damage and repair factor mis-localization with stem cells and cancer cells, with evidence of invasion-mutation providing insight into mutation scaling in cancer. Systems Genetics of Tuberculosis , Apr 26 Bridging the gap between the spatial and mnemonic views of the hippocampus, Apr 27 This seminar is partially sponsored by NIH Physical Mechanisms of Cell Organization on Micron Length Scales, May 1 Innate-like B cells and their rules of engagement in infection, May 2 This seminar is partially sponsored by NIH Deconstructing and reconstructing microbial communities using cheese, May 2 Sculpting the nervous system: Cellular and molecular mechanismsof neural circuit refinement, May 4 This seminar is partially sponsored by NIH Department of Molecular and Cell Biology Annual Alumni Seminar: Structure and strategy in host-pathogen conflicts, May 5 Department of Molecular & Cell Biology Annual Alumni Seminar<br /> How do you build a functional ciliated cell?, May 8 Most of our cells grow one or more cilia at some point in their lifetime, which is essential for many major developmental morphogenetic events and adult tissue functions. Ciliary defects underlie a growing list human disorders termed ciliophathies and have been linked to diseases and conditions such as cancer, tissue fibrosis and obesity - thus, it is important to understand how we build and maintain functional ciliated cells. I focus on the multiciliated cells (MCCs) of the mammalian airway epithelium, which make hundreds of motile cilia whose directional movement clears the respiratory tract of inhaled pathogens, allergens, toxins and debris. Ciliary clearance is our first line of defense against these contaminants, and it is vital for maintaining healthy lungs. I study how the MCC fate is specified, how MCCs generate hundreds of motile cilia (since most cells are only allowed to make a solitary primary cilium), and how they orient their cilia along the tissue axis for directional airway clearance. My goal is to uncover the principles of cilium biogenesis and of ciliary number control and function, and thus bring us closer to realizing unmet tissue engineering goals and cell based, genetic or other treatment of ciliopathies. Special MCB-IB Postdoc Lunch, May 12 Understanding and overcoming drug resistance in cancer, May 16 This seminar is partially sponsored by NIH Genetically encoded tools for manipulation of metabolism in living cells, May 16 Cytotoxic T lymphocyte lytic synapses in human health and disease, May 22 This seminar is partially sponsored by NIH CryoEM snapshots of the spliceosome at work: Insights into its Catalytic Mechanism, May 22 This seminar is partially sponsored by NIH Interferon-inducible GTPases in host resistance and inflammation, May 23 This seminar is partially sponsored by NIH Choreography of bacterial nanomotors revealed by live-cell imaging, Oct 25 Roger Y. Stanier Memorial Lecture<br /> Department of Molecular and Cell Biology Annual Capstone Lecture, Dec 8 Department of Molecular & Cell Biology Annual Capstone Lecture<br />