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DTSTAMP:20111024T220835Z
DTSTART;TZID=America/Los_Angeles:20111102T120000
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SUMMARY:“Engineering the innate immune response to improve healing of infected wounds”
UID:48709-ucb-events-calendar@berkeley.edu
ORGANIZER;CN="UC Berkeley Calendar Network":
LOCATION:106 Stanley Hall
DESCRIPTION:Scott Simon\, University of California\, Davis\n\nFall 2011 Seminar Series\nSponsored by Novartis Diagnostics\n\nWednesday\, November 2\n12noon - 1:00pm\n106 Stanley Hall\, UC Berkeley\n\n“Engineering the innate immune response to improve healing of infected wounds”\n\nScott Simon\nDepartment of Biomedical Engineering \nUniversity of California\, Davis\n\nPolymorphonuclear neutrophils (PMNs) are critical for the formation\, maintenance and resolution of bacterial abscesses. However\, the mechanisms that regulate PMN number\, survival\, and proliferation during the evolution of an abscess are not well defined. Using a mouse model of Staphylococcus aureus-abscess formation within a skin wound combined with real time imaging of genetically tagged PMNs\, we observed that a high bacterial burden elicited a sustained mobilization of PMN from bone marrow to the infected wound where their lifespan was markedly extended. A continuous rise in wound PMN number that was not accounted for by trafficking from the bone marrow or prolonged survival correlated with homing of hematopoietic progenitor cells from blood to the wound where they proliferated and formed mature PMNs. This seminar will review innate immune cell dynamics responding to infection and consider novel pathways to manipulate signaling pathways that control PMN survival and local proliferation for improved wound resolution.\n\nHosted by Professor Song Li
URL:http://events.berkeley.edu/index.php/calendar/sn/pubaff.html?event_ID=48709&view=preview
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