Amgen Seminar in Organic Chemistry: Twists and turns along the path of reactivity-driven methodology development
Seminar | December 3 | 11 a.m.-12 p.m. | 120 Latimer Hall
Carbocations are important reactive intermediates that are invoked in many chemical transformations. These species are usually of the tricoordinated variety. Conversely, dicoordinated carbenium ions are rarely invoked as intermediates in practical chemical processes due to their high energy and energetically challenging formation. In this talk I will discuss our recent efforts to utilize phenyl and vinyl carbocations in CH functionalization reactions. We will describe how these high-energy dicoordinated carbocations can be generated under mild conditions and utilized in the selective CC bond forming reactions of simple hydrocarbons. Moreover, we will discuss our efforts to understand the mechanism of these reactions through computational chemistry, kinetics, electron microscopy, and isotopic labeling studies.