Perturbation and Control of Human Brain Network Dynamics

Seminar | May 3 | 3:30-4:30 p.m. | 101 Life Sciences Addition

 Dani Bassett, University of Pennsylvania

 Neuroscience Institute, Helen Wills

Abstract: The human brain is a complex organ characterized by heterogeneous patterns of interconnections. New non-invasive imaging techniques now allow for these patterns to be carefully and comprehensively mapped in individual humans, paving the way for a better understanding of how wiring supports our thought processes. While a large body of work now focuses on descriptive statistics to characterize these wiring patterns, a critical open question lies in how the organization of these networks constrains the potential repertoire of brain dynamics. In this talk, I will describe an approach for understanding how perturbations to brain dynamics propagate through complex writing patterns, driving the brain into new states of activity. Drawing on a range of disciplinary tools – from graph theory to network control theory and optimization – I will identify control points in brain networks, characterize trajectories of brain activity states following perturbation to those points, and propose a mechanism for how network control evolves in our brains as we grow from children into adults. Finally, I will describe how these computational tools and approaches can be used to better understand how the brain controls its own dynamics (and we in turn control our own behavior), but also how we can inform stimulation devices to control abnormal brain dynamics, for example in patients with severe epilepsy.