In order to enhance scientific knowledge and engineering capability in nano scale, it is crucial to develop manipulation tools (e.g., nano hands) for handling an individual nano object or molecule, as well as to establish an advanced characterization method with single atomic or molecular level sensitivity and with simultaneous imaging capability (e.g., nano eyes).
The author and his colleagues have intensively investigated MEMS design, fabrication, and its application to nano and bio technologies. Nano scientific research using a MEMS-in-TEM setup covers the tensile and shear testing and the heat transfer measurement of nano junctions in transmission electron microscopes (TEM) for in situ atomic level observation of the junctions. MEMS for bio technology includes MEMS tweezers for electro-chemo-mechanical characterization of DNA molecules, microfuidic characterization of microorganisms (Vorticella picta), micromachined fL-chambers and heaters to allow single molecular-level enzymology, and the bio molecular motors reconstructed in MEMS for direct sorting and transportation of specific sample molecules. In this talk, I will focus on three topics: MEMS-in-TEM; MEMS tweezers for characterizing chemical and radiation effects on DNA molecules; the reconstructed bio molecular motor system to detect the interaction between the tau protein (a promising bio-marker for Alzheimers disease) and microtubules.
July 9 .