Making Sense of Pain: A Human Genetics Driven Multi-disciplinary, Multi-modality Approach to Drug Discovery

Seminar: Organic Chemistry | September 19 | 11 a.m.-12 p.m. | 120 Latimer Hall

 Dr. Margaret Chu-Moyer, Executive Director, Research, Amgen

 College of Chemistry

Recent advances in human genetics have allowed deeper insight into disease biology. Coupling of this to the development of molecules to further understand relevant pharmacology and to identify potential therapeutics has never been more important or more challenging. This lecture will demonstrate the scientific interplay that is necessary to discover human medicines using a recent multi-modality example from our Neuroscience portfolio (Nav1.7 inhibitors for treatment of pain) and will include discussion of target validation, structural biology, lead optimization in medicinal chemistry and pharmacokinetic/pharmacodynamics relationships.

 Light refreshments will be served at 10:50 at The Coffee Lab, 510-643-0572