ABOUT THE CALENDAR
Bridging the Gap Between the Petri Dish and the Patient: Integrative Approaches to Put Disease in Context
Seminar: BioE Seminars: Seminars of interest | March 14 | 12-1 p.m. | 106 Stanley Hall
Stephanie Fraley, University of California, San Diego
Technological advances continue to accentuate the fact that biological knowledge is highly context and time dependent. It is now clear that in vitro model systems, which are necessary for studying the molecular mechanisms of disease, fail to represent many critical pathophysiological features of human disease. Thus, findings from in vitro studies rarely translate directly into impact for patients. A major challenge remains the development of a scientific framework capable of capturing critical disease features in a dish and bridging knowledge flow between in vitro and clinical understanding of human disease. In particular, diseases that involve complex microenvironmental deregulation, like cancer, are needed. This will require innovation in identifying, characterizing, and recapitulating key aspects of three-dimensional (3D) tissue architectures to study dynamic cell-microenvironment relationships. My lab is developing and validating strategies on both the in vitro and clinical side of this problem to bridge the knowledge gap with the goal of significantly increasing the translation rate of basic science studies.
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