Wednesday, April 5
12noon - 1:00pm
290 Hearst Mining Building
Probing the biophysical regulation of de novo tumor microenvironment
Tissue Morphodynamics Unit, Laboratory for Cell Biology,
Center for Cancer Research, National Cancer Institute,
National Institutes of Health
Metastasis to distant organs remains the lethal outcome in most malignant tumors. The role of the microenvironment is emerging as critical for malignant progression, metastasis and tumor etiology. Specifically, the interactions between tumor cells and the extracellular matrix (ECM), normal cells and immune cells are critical to establish the metastatic niche. Our goal is to dissect the universal physical attributes that a tumor cell must possess to successfully colonize a foreign organ. Namely the cell must be able to invade, adhere and proliferate while evading the immune system. To address these questions, we use biophysical tools to measure forces that cells use to actively remodel and create the microenvironmental niche using 3D cell culture models for metastasis and similar assays in zebrafish.