Skip to main content.
Advanced search >
<< Back to previous page Print

<< Friday, January 19, 2018 >>


Remind me

Tell a friend

Add to my Google calendar (bCal)

Download to my calendar

Bookmark and ShareShare


Cryo-EM Visualization of Microtubules to Understand Their Regulated Dynamics: Nano Seminar Series

Seminar | January 19 | 1-2 p.m. | 390 Hearst Memorial Mining Building


Prof. Eva Nogales, UC Berkeley / LBNL, Biochemistry

Berkeley Nanosciences and Nanoengineering Institute


Visualizing macromolecular assemblies, in different functional states, provides unique information on how they work in the cell and how they fail in the diseased state, and therefore can guide us in the design and improvement of therapies. But their small size and sensitivity to radiation makes visualization of biological molecules challenging and requires employment of highly specialized instruments and computational tools.

Technological developments in the field of cryo-electron microscopy (cryo-EM) are now allowing the fast turn-around of structural information on critical cellular components. As an example, I will talk about what we have learned, through the visualization at atomic resolution using cryo-EM, about microtubules, critical cytoskeletal polymers that are essential for cell division and a major anticancer target.

*****
Eva Nogales did her BS in physics in Madrid, PhD in biophysics at Keele, and postdoc at LBNL where she rose to senior faculty scientist in 2008. She is also an HHMI Investigator, headed the Biophysics Graduate Program ('12-'15), and today heads the Berkeley Cryo-EM facility BACEM. Notable awards include Distinguished Role Model in the Life Sciences and election to both AAAS and the NAS, and is currently assoc editor of the Journal of Structural Biology.


510-643-6681