Wednesday, September 19, 2018

Center for Computational Biology Seminar: Dr. Zhijin (Jean) Wu, Associate Professor of Biostatistics, Brown University

Seminar: Bioinformatics Seminars | September 19 | 4:30-5:30 p.m. | 101 Life Sciences Addition

 Center for Computational Biology

Title: Two-phase differential expression analysis for single cell RNA-seq

Abstract: Single-cell RNA-sequencing (scRNA-seq) has brought the study of the transcriptome to higher resolution and makes it possible for scientists to provide answers with more clarity to the question of ‘differential expression’. Specifically, it allows us to observe binary (On/Off) as well as continuous (the amount...   More >

Wednesday, October 3, 2018

Center for Computational Biology Seminar: Dr. Quaid Morris, Professor, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto

Seminar: Bioinformatics Seminars | October 3 | 4:30-5:30 p.m. | 101 Life Sciences Addition

 Center for Computational Biology

Title: Making sense of the “noise” in cancer data

Wednesday, December 5, 2018

Center for Computational Biology Seminar: Dr. Angela Brooks, Assistant Professor, UC Santa Cruz

Seminar: Bioinformatics Seminars | December 5 | 4:30-5:30 p.m. | 101 Life Sciences Addition

 Center for Computational Biology

Full-length alternative transcript isoform analysis with nanopore sequencing

Abstract:
Our group aims to understand the mechanisms of alternative RNA splicing regulation and splicing dysregulation in cancer. Short-read, high-throughput cDNA sequencing (RNA-Seq) has revolutionized our ability to profile RNA splicing; however, this approach cannot capture the full complexity of RNA...   More >

Wednesday, February 6, 2019

Center for Computational Biology Seminar: Dr. Beth Shapiro, Professor, UC Santa Cruz

Seminar: Bioinformatics Seminars | February 6 | 4:30-5:30 p.m. | 125 Li Ka Shing Center

 Center for Computational Biology

Genomics, genetic rescue, and the future of conservation

Abstract: New technologies, including complete genome sequencing and genome engineering, promise to revolutionize conservation and slow the pace of the ongoing extinction crisis. However, the value of these technologies to conservation remains unclear. Using mountain lions from across their range and wolves from Isle Royale as examples,...   More >

Thursday, February 14, 2019

Center for Computational Biology and Koret Berkeley Tel Aviv Initiative Seminar: Dr. Ron Shamir, Professor, Tel Aviv University

Seminar | February 14 | 4-5 p.m. | 125 Li Ka Shing Center

 Center for Computational Biology, Koret Berkeley Tel Aviv Initiative

Integrated analysis of cancer data: multi-omic clustering and personalized ranking of driver genes

Abstract: Large biological datasets are currently available, and their analysis has applications to basic science and medicine. While inquiry of each dataset separately often provides insights, integrative analysis may reveal more holistic, systems-level findings. We demonstrate the power of...   More >

Wednesday, March 6, 2019

Center for Computational Biology Seminar: Dr. Shamil Sunyaev, Department of Biomedical Informatics, Harvard Medical School

Seminar: Bioinformatics Seminars | March 6 | 4:30-5:30 p.m. | 125 Li Ka Shing Center

 Center for Computational Biology

Large-scale genomic data reveal mechanisms of mutagenesis and help predict complex phenotypes

Abstract:
Statistical analysis of large genomic datasets has recently emerged as a discovery tool in many areas of genetics. Two examples include studies of mutagenesis and of the relationship between genotype and phenotype. We developed a statistical model of regional variation of human mutation...   More >

Thursday, March 14, 2019

Priya Moorjani | Reconstructing South Asian Population History using Genetic Data: Priya Moorjani | Reconstructing South Asian Population History using Genetic Data

Lecture | March 14 | 5-7 p.m. | Stephens Hall, 10 (ISAS Conf. Room)

 Priya Moorjani, Assistant Professor, Department of Molecular & Cell Biology, UC Berkeley

 Munis D. Faruqui, Director, Institute for South Asia Studies; Sarah Kailath Chair of India Studies; Associate Professor, South & South East Asian Studies

 Center for Computational Biology, Institute for South Asia Studies, Sarah Kailath Chair of India Studies, Population Center, Population Science, Department of Demography

Talk by molecular biologist and geneticist, Professor Priya Moorjani.

Monday, March 18, 2019

Quantitative analysis of energy metabolism: Dr. Sheng Hui, Lewis-Sigler Institute for Integrative Genomics, Princeton University

Seminar | March 18 | 4-5 p.m. | 101 Morgan Hall

 Center for Computational Biology, Nutritional Sciences and Toxicology

Abstract:
Mammals generate energy by burning dietary carbon into CO2. The largest calorie source for most mammals is carbohydrate, which is broken down into glucose in the small intestinal lumen. Glucose is then absorbed and circulates in the blood stream. To acquire energy, tissues are generally assumed to take in glucose and break it down to CO2 through the concerted action of glycolysis and...   More >

Thursday, March 21, 2019

Modeling Cellular Programs and Interactions Underlying Innate Immune Response: Dr. Samantha Riesenfeld, Broad Institute, MIT and Harvard University

Seminar | March 21 | 4-5 p.m. | 114 Morgan Hall

 Center for Computational Biology, Nutritional Sciences and Toxicology

Abstract:
To protect the host and maintain tissue homeostasis, the immune system responds not only to a vast array of pathogens, but also to environmental cues, for example, signals of tissue injury or changes in nutrient availability. Innate lymphoid cells (ILCs) are a type of immune cell that play a role in maintaining a stable environment and barrier in mucosal tissues but can also promote...   More >

Monday, April 1, 2019

Population Diversity in Aging and Metabolic Stress: Using Systems Biology to Connect Molecular Networks and Phenotypic Outcomes: Dr. Evan Williams, Institute of Molecular Systems Biology, ETH Zurich

Seminar | April 1 | 4-5 p.m. | 114 Morgan Hall

 Center for Computational Biology, Nutritional Sciences and Toxicology

Abstract:
Interactions between individuals' genetic backgrounds and their environments over a lifetime drive variation in the incidence and severity of metabolic disorders and age-related co-morbidities. We have followed a highly diverse set...   More >

Thursday, April 4, 2019

New approaches for uncovering the role of energy metabolism in health and disease: Dr. Denis Titov, Molecular and Cell Biology Department, UC Berkeley

Seminar | April 4 | 4-5 p.m. | 114 Morgan Hall

 Center for Computational Biology, Nutritional Sciences and Toxicology

Abstract:
Over the last century, many studies have demonstrated that calorie restriction (i.e. decreased food intake) and exercise cause lifespan extension in model organisms and decrease human mortality from age-associated diseases. Many physiological changes...   More >

Wednesday, May 1, 2019

Center for Computational Biology Seminar: Sohini Ramachandran, Associate Professor, Brown University

Seminar: Bioinformatics Seminars | May 1 | 4:30-5:30 p.m. | 125 Li Ka Shing Center

 Center for Computational Biology

Leveraging linkage disequilibrium to identify adaptive and disease-causing mutations

Abstract:
Correlation among genotypes in human population-genetic datasets complicates the localization of both adaptive mutations and disease-causing mutations. I will describe our latest efforts to develop new methods for localizing adaptive and disease-causing mutations, motivated by (1) incorporating...   More >

Wednesday, July 24, 2019

Center for Computational Biology Seminar: Dr. Michal Linial, Professor of Biochemistry and Bioinformatics, Hebrew University of Jerusalem

Seminar | July 24 | 12-1 p.m. | 106 Stanley Hall

 Center for Computational Biology

Not all proteins are created equal: Finding solution in translational control

Abstract:
Protein synthesis is an indispensable process which accounts for a large proportion of the energetic resources of any living cells. Therefore, translational regulation must be tightly controlled. Such regulation is critical for protein biogenesis, folding, trafficking and degradation under stable and...   More >

Wednesday, September 4, 2019

Center for Computational Biology Seminar: Combining DNA Synthesis, Multiplexed Reporters, and Genome Engineering to better Understand Human Gene Regulation and Protein Function

Seminar: Bioinformatics Seminars | September 4 | 4-5 p.m. | 125 Li Ka Shing Center

 Sriram Kosuri, Assistant Professor, UCLA

 Center for Computational Biology

Sri Kosuri is an alumnus of UC Berkeley (BS, Bioengineering '01; Go Bears) and an Associate Professor in the Department of Chemistry and Biochemistry at UCLA, with appointments in the Institute for Quantitative and Computational Biology, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Broad Stem Cell Center, and the Jonsson Comprehensive Cancer Center. The Kosuri...   More >

Wednesday, October 2, 2019

Thursday, November 14, 2019

Thursday, December 12, 2019

Wednesday, February 5, 2020

Thursday, March 5, 2020

Wednesday, April 1, 2020

Center for Computational Biology Seminar

Seminar: Bioinformatics Seminars | April 1 | 4-5 p.m. | 125 Li Ka Shing Center

 Sean Eddy, Professor, Harvard University

 Center for Computational Biology

Wednesday, May 6, 2020

Center for Computational Biology Seminar

Seminar: Bioinformatics Seminars | May 6 | 4-5 p.m. | 125 Li Ka Shing Center

 William Noble, Professor, University of Washington

 Center for Computational Biology