<< Monday, December 09, 2019 >>

Monday, December 9, 2019

Andrew Braisted Award Lecture: "Radicals: Your Life is in their Hands RNR as a Paradigm"

Lecture | December 9 | 4-5 p.m. | 106 Stanley Hall

 JoAnne Stubbe, Massachusetts Institute of Technology

 College of Chemistry

Ribonucleotide reductases (RNRs) catalyze the de novo reduction of NDPs to dNDPs in all organisms, controlling their relative ratios and amounts and contributing to the fidelity of DNA replication and repair. The class Ia RNRs are composed of a2 and b2 subunits that form an active and dynamic a2b2 complex. Studies with mechanism-based inhibitors have revealed half-sites reactivity with only one...   More >