Bioengineering Rising Star Lecture - Krishanu Saha: Towards nonviral, in vivo genome editing therapies: new tools and models to facilitate translation

Seminar | November 20 | 12-1 p.m. | 106 Stanley Hall

 Krishanu Saha, Wisconsin Institute for Discovery

 Bioengineering (BioE)

Krishanu Saha, Associate Professor
Department of Biomedical Engineering & Wisconsin Institute for Discovery, Retina Research Foundation Kathryn and Latimer Murfee Chair

"Towards nonviral, in vivo genome editing therapies: new tools and models to facilitate translation"

We have developed new approaches to inform first-in-human studies that combine patient-derived, induced pluripotent stem cell models with new delivery nanocarriers and computational models. Our results indicate that mutation-specific, CRISPR-Cas9 genome editors can be designed to efficiently target mutant alleles without substantial off-target effects.

 510-642-5833