Solid State Technology and Devices Seminar: Optoelectronic Tweezers – A New Optofluidic Platform for Digital Cell Biology

Seminar | September 28 | 1-2 p.m. | Cory Hall, 521 Hogan Room

 Ming C. Wu, Electrical Engineering and Computer Sciences Dept., University of California, Berkeley

 Electrical Engineering and Computer Sciences (EECS)

Recent success stories of treating cancer with immunotherapy has generated tremendous excitement in the last few years. The remarkable treatment of former President Jimmy Carter’s cancer was widely publicized. Immunotherapy uses the antibodies produced by white blood cells, or the cells themselves, to boost the immune response of patients to fight cancer cells. The discovery and production of such “biological drugs” require efficient screening and analysis of a large number of individual white blood cells. In this talk, I will discuss an optofluidic technology developed at Berkeley several years ago called “optoelectronic tweezers” (OET). OET enables cloning of single cells in sub-nanoliter compartments in a microfluidic chip. Antibodies produced by individual cells can be measured in hours. The fully automated OET instruments are now helping pharmaceutical industries speed up drug discovery and production process.

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