Between-individual variation in the human retina ultrastructure: the key for understanding everything from myopia to AMD?

Seminar | May 6 | 11:10 a.m.-12:30 p.m. | 489 Minor Hall

 Rigmor Baraas, OD, PhD, National Centre for Optics, Vision and Eye Care, Department of Optometry, Radiography and Lighting Design, University of South-Eastern Norway, Kongsberg, Norway

 Neuroscience Institute, Helen Wills

Optical coherence tomography (OCT) and adaptive optics scanning light ophthalmoscopy (AOSLO) have become invaluable tools for mapping the ultrastructure of the retina in living humans. OCT imaging has revealed considerable variation in retinal layer thickness, foveal shape and morphology. AOSLO imaging has revealed large variation in cone mosaics, both peak and eccentricity dependence density variation. Now we can utilize multimodal AOSLO to map the retinal pigment epithelium mosaic and its inter-relationship with photoreceptors.
This talk will describe ongoing work studying between-individual differences in ultrastructure organization and inter-relationship between the cone photoreceptor and retinal pigment epithelium mosaics and foveal morphology. By combining data from these imaging modalities with statistical modelling, we are aiming to make progress in understanding the implications this variation may have on eye growth and health.