Dopamine Diversity: Tasks, Projections and Channels
Seminar | March 9 | 3-4 p.m. | 125 Li Ka Shing Center
Dr. Jochen Roeper, Director, Institute of Neurophysiology, Goethe University Frankfurt
Dopamine (DA) midbrain neurons that in reside in the two neighboring nuclei substantia nigra (SN) and ventral tegmental area (VTA) have segregated according to their axonal projections into several mostly parallel systems with different functions in the control of action, reward-based learning and cognition. In vivo electrophysiology in awake freely moving mice demonstrates functionally distinct DA subpopulations related to different task aspect, while a combination of retrograde tracing and in vivo recording with juxtacellular labelling reveals that distinct electrophysiological baseline features are associated with both projection (target) and location (source). Finally, we show how different DA subpopulations used different ion channels to boost phasic burst or pause responses.
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