Measuring activity of cortical layers in human brain with CBV-fMRI: method and first applications

Seminar | February 26 | 4-5 p.m. | 125 Li Ka Shing Center

 Laurentius Huber, Postdoc Fellow at Section on Functional Imaging Methods, NIMH, NIH

 Neuroscience Institute, Helen Wills

Layer-dependent fMRI allows measurements of information flow in cortical circuits, as afferent and efferent connections terminate in different cortical layers.
However, conventional high-resolution fMRI is challenged by its reactively high noise level and limited localization specificity of large draining veins.
In this presentation, I will discuss some recent methodological advancements of cerebral-blood-volume (CBV)-sensitive fMRI with VASO to achieve a good sensitivity-specificity tradeoff in layer fMRI. Furthermore, I will discuss applications of measuring directional connectivity in the human cortex with the focus on th sensory-motor system, DLPFC, and V1.

Huber L..Bandettini, Neuron. 2017 Dec 20;96(6):1253-1263.e7. doi: 10.1016/j.neuron.2017.11.005. Epub 2017 Dec 7.