Recent Advances in Biomedical Surface Analysis: Proteins and Nanoparticles
Seminar | November 13 | 4-5 p.m. | 120 Latimer Hall
Surface analysts have benefited from the significant and numerous advances that have occurred in the past 40 years in terms of improved instrumentation, introduction of new techniques and development of sophisticated data analysis methods, which has allowed us to perform detailed analysis of increasing complex samples. For example, comprehensive analysis of surfaces and surface immobilized proteins with modern surface analysis instrumentation provides an unprecedented level of detail about the immobilization process and the structure of the immobilized proteins. Results from x-ray photoelectron spectroscopy (XPS), time-of-flight secondary ion mass spectrometry (ToF-SIMS), near edge x-ray absorption fine structure (NEXAFS), surface plasmon resonance (SPR) and quartz-crystal microbalance with dissipation (QCM-D) biosensing, atomic force microscopy, and sum frequency generation (SFG) vibrational spectroscopy combined with computation methods such as molecular dynamic (MD) and Monte Carlo (MC) simulations provide important information about surface chemistry and structure. However, even with the advances that have been achieved with these powerful surface science techniques, there still remain many significant challenges for surface analyst. These include characterizing the surface chemistry and structure of nanoparticles, determining the atomic level structure of proteins bound to surfaces, 3D imaging of samples, and improved sample preparation methods that maintain materials in a relevant state when using ultra-high vacuum based analysis techniques. This talk will focus on recent biomedical surface analysis advances in the areas of immobilized proteins and nanoparticles.
Light refreshments will be served at 3:50 at The Coffee Lab