Muetterties Seminar: Supramolecular approaches to control selectivity in transition metal catalysis
Seminar | February 14 | 4-5 p.m. | Sutardja Dai Hall, Banatao Auditorium
The interface between supramolecular chemistry and transition metal catalysis has received surprisingly little attention in contrast to the individual disciplines. It provides, however, novel and elegant strategies that lead to new tools for the search of effective catalysts, and as such this has been an important research theme in our laboratories. In this presentation I will focus
on supramolecular strategies to control activity and selectivity in transition metal catalysis, which is especially important for reactions that are impossible to control using traditional catalyst development. For substrates with functional groups we use substrate orientation
effects to control selectivity. We demonstrate that hydrogen bonding is a versatile tool to control the substrate orientation at the metal center, and that this is an excellent tool to achieve highly enantioselective hydrogenation catalysts, highly regioselective hydroformylation, Heck and CH borylation catalysts.