Merck Seminar in the Chemical Sciences: A few of my favorite rings: Catalysis inspired by macrocycles
Seminar | November 6 | 11 a.m.-12 p.m. | 120 Latimer Hall
Lactones and lactams make up a range of structurally complex and functional compounds, from antibiotics to nanomaterials. Inspired by Nature's cyclic architectures, we are developing catalytic methods that feature stereoselective hydroacylation. Hydroacylation, the formal addition of an aldehyde CH bond across an unsaturated functional group, is an ideal approach to carbonyl functionalities commonly found in bioactive molecules. We aim to advance hydroacylation as a unified strategy for transforming aldehydes into chiral esters, ketones, and amides. In this context, my lecture will discuss the design, scope, and mechanism for hydroacylation methods using both rhodium and cobalt catalysis. This goal led us to the serendipitous discovery of a strategy for one-carbon dehomologation featuring aldehyde C-H bond activation. The mechanism of this transfer hydroformylation along with its potential applications in both natural product synthesis and the petroleum industry will be highlighted.
Light refreshments will be served at 10:50 at The Coffee Lab