Total synthesis of polycyclic natural products
Seminar | October 9 | 11 a.m.-12 p.m. | 120 Latimer Hall
Syntheses of some polycyclic alkaloids and terpenoids by our group will be presented in this lecture. Daphniphyllum alkaloids are a class of structurally intriguing natural products. We develop a series of strategies, such as electrocyclization, [3 + 2] cycloaddition, electrocyclic ring opening, and late-stage Diels−Alder cycloaddition, to achieve the syntheses of a dozen of them. Inspired by a Prins reaction in the biogenesis of a Daphniphyllum alkaloid, we developed Prins cyclization strategies for the construction of sterically congested ring systems of some terpenoids, in particular those containing tetrasubstituted olefins.
Light refreshments will be served at 10:50 at The Coffee Lab