Abiotic synthetic polymers: functional alternatives to antibodies? Applications for protein stabilization, inhibition of signal transduction and as broad-spectrum antivenom.
Seminar | October 2 | 11 a.m.-12 p.m. | 120 Latimer Hall
Nanoparticles (NPs), when introduced into biological fluids, acquire a corona consisting of physically adsorbed proteins. The composition of the corona is a function of many variables including the chemical composition of the NP, its size, shape and duration of the exposure. We posed the question; can the chemical composition of a synthetic polymer nanoparticle be engineered to control the composition of the protein corona? We will describe synthesis of abiotic hydrogel polymer NPs engineered with antibody-like affinity and selectivity for targeted biomacromolecules. Application areas in medicine and biology include protein stabilization, isolation and purification, inhibition of signal transduction and as broad-spectrum antivenom.
Light refreshments will be served at 10:50 at The Coffee Lab