Systems Approaches for Understanding Antimicrobial Efficacy
Seminar | February 23 | 12-1 p.m. | Sibley Auditorium, Bechtel Engineering Center
Jason Yang, Massachusetts Institute of Technology
Recent advances in high-throughput experimental technologies and data analytics now enable unprecedented quantification and association of biological signals with markers of human health and disease; but current efforts to harness this potential fail to reliably produce the mechanistic biological insights necessary for driving translational innovation. Here, we will discuss systems approaches for understanding the mechanistic basis of in vivo antimicrobial efficacy. We will first describe insights gained on bacterial physiology, immune cell physiology and the host-pathogen interface by biochemically profiling a peritoneal infection in mice using mass spectroscopy. We will next discuss how genomescale models of physiology may be used to enrich the information content in biological screens; and describe insights gained on metabolic processes contributing to antibiotic lethality using models of bacterial metabolism. Finally, we will discuss how these approaches may be extended to complex human diseases and be applied to discover next-generation therapies.