Glenn T. Seaborg Lecture in Inorganic Chemistry: Endowing Organometallic Catalysis with a Genetic Memory

Seminar | November 3 | 4-5 p.m. | 120 Latimer Hall

 Thomas Ward, University of Basel

 College of Chemistry

With the aim of integrating artificial metalloenzymes in vivo, the second talk will present our efforts to combine ArMs with natural enzymes to mimic fundamental features of the metabolism including: cascade reactions, up- and cross-regulation. Having identified the critical metabolites leading to ArM’s inhibition in cellulo, our efforts towards performing catalysis in the periplasm of E. coli will be highlighted.

Scheme. Anchoring a catalyst precursor (ball & stick representation) within a host protein (baseball glove) affords an artificial metalloenzyme. The catalytic performance of the resulting hybrid catalyst can be optimized by chemo-genetic means: variation of the nature and position of the cofactor (turquoise stick representation) and mutation of aminoacid residues (green stick representation).

 Light refreshments will be served at 3:50 at The Coffee Lab, 510-643-0572