Catalytic Approaches to Simplifying Synthesis
Seminar | October 10 | 11 a.m.-12 p.m. | 120 Latimer Hall
Catalysts that provide new reactivity and stereocontrol in efficient bond-forming reactions, are essential tools for converting low cost starting materials into high value, structurally complex, stereochemically defined product materials. In this presentation, new families of metal-free and metal-rich cooperative catalysts and their use in highly enantioselective C-C bond forming reactions and other relevant transformations, will be described.
Their strategic application to the discovery of new one-pot reaction cascade processes to generate novel, stereochemically defined scaffolds and architectures useful for library and target synthesis will also be discussed. Further application of selected methodologies as pivotal carbon-carbon bond forming steps in the total synthesis of a range of manzamine, aspidosperma, iboga, strychnos and daphniphyllum alkaloids will then be discussed. These syntheses serve to illustrate how complex molecular targets can be rapidly accessed when combinations of catalyst-controlled reactions, one-pot multistep procedures and powerful route-shortening cascades are designed into the overall synthetic sequence.
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Light refreshments will be served at 10:50 at The Coffee Lab