Plant and Microbial Biology Plant Seminar: “What makes heterochromatin epigenetic? Lessons from a single cell spreading sensor”

Seminar | April 4 | 12-1 p.m. | 101 Barker Hall

 Bassem Al-Sady, University of California San Francisco

 Department of Plant and Microbial Biology

The Al-Sady lab interests reside in uncovering the mechanisms that underlie the assembly and fidelity of inheritance of heterochromatin, a specialized protein-nucleic acid composite. Unraveling these mechanisms is key to understanding the manner in which large stretches of the genome can be precisely and heritably partitioned into active and inactive regions. The heterochromatin system presents some unique and unusual features for a cellular self-assembly, such as nucleated, template-guided polymerization to a precise positional extent that have remained difficult to study. Addressing these features requires a multidisciplinary framework integrating biochemical and novel single cell genetic approaches.

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